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Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy
Photo-nanotheranostics integrates near-infrared (NIR) light-triggered diagnostics and therapeutics, which are combined into a novel all-in-one phototheranostic nanomaterial that holds great promise for the early detection and precise treatment of cancer. In this study, we developed methylene blue-lo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612258/ https://www.ncbi.nlm.nih.gov/pubmed/36297675 http://dx.doi.org/10.3390/pharmaceutics14102242 |
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author | Seo, Sun-Hwa Joe, Ara Han, Hyo-Won Manivasagan, Panchanathan Jang, Eue-Soon |
author_facet | Seo, Sun-Hwa Joe, Ara Han, Hyo-Won Manivasagan, Panchanathan Jang, Eue-Soon |
author_sort | Seo, Sun-Hwa |
collection | PubMed |
description | Photo-nanotheranostics integrates near-infrared (NIR) light-triggered diagnostics and therapeutics, which are combined into a novel all-in-one phototheranostic nanomaterial that holds great promise for the early detection and precise treatment of cancer. In this study, we developed methylene blue-loaded mesoporous silica-coated gold nanorods on graphene oxide (MB-GNR@mSiO(2)-GO) as an all-in-one photo-nanotheranostic agent for intracellular surface-enhanced Raman scattering (SERS) imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) for cancer. Amine functionalization of the MB-GNR@mSiO(2) surfaces was performed using 3-aminopropyltriethoxysilane (APTES), which was well anchored on the carboxyl groups of graphene oxide (GO) nanosheets uniformly, and showed a remarkably higher photothermal conversion efficiency (48.93%), resulting in outstanding PTT/PDT for cancer. The in vitro photothermal/photodynamic effect of MB-GNR@mSiO(2)-GO with laser irradiation showed significantly reduced cell viability (6.32%), indicating that MB-GNR@mSiO(2)-GO with laser irradiation induced significantly more cell deaths. Under laser irradiation, MB-GNR@mSiO(2)-GO showed a strong SERS effect, which permits accurate cancer cell detection by SERS imaging. Subsequently, the same Raman laser can focus on highly detected MDA-MB-23l cells for a prolonged time to perform PTT/PDT. Therefore, MB-GNR@mSiO(2)-GO has great potential for precise SERS imaging-guided synergistic PTT/PDT for cancer. |
format | Online Article Text |
id | pubmed-9612258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96122582022-10-28 Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy Seo, Sun-Hwa Joe, Ara Han, Hyo-Won Manivasagan, Panchanathan Jang, Eue-Soon Pharmaceutics Article Photo-nanotheranostics integrates near-infrared (NIR) light-triggered diagnostics and therapeutics, which are combined into a novel all-in-one phototheranostic nanomaterial that holds great promise for the early detection and precise treatment of cancer. In this study, we developed methylene blue-loaded mesoporous silica-coated gold nanorods on graphene oxide (MB-GNR@mSiO(2)-GO) as an all-in-one photo-nanotheranostic agent for intracellular surface-enhanced Raman scattering (SERS) imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) for cancer. Amine functionalization of the MB-GNR@mSiO(2) surfaces was performed using 3-aminopropyltriethoxysilane (APTES), which was well anchored on the carboxyl groups of graphene oxide (GO) nanosheets uniformly, and showed a remarkably higher photothermal conversion efficiency (48.93%), resulting in outstanding PTT/PDT for cancer. The in vitro photothermal/photodynamic effect of MB-GNR@mSiO(2)-GO with laser irradiation showed significantly reduced cell viability (6.32%), indicating that MB-GNR@mSiO(2)-GO with laser irradiation induced significantly more cell deaths. Under laser irradiation, MB-GNR@mSiO(2)-GO showed a strong SERS effect, which permits accurate cancer cell detection by SERS imaging. Subsequently, the same Raman laser can focus on highly detected MDA-MB-23l cells for a prolonged time to perform PTT/PDT. Therefore, MB-GNR@mSiO(2)-GO has great potential for precise SERS imaging-guided synergistic PTT/PDT for cancer. MDPI 2022-10-20 /pmc/articles/PMC9612258/ /pubmed/36297675 http://dx.doi.org/10.3390/pharmaceutics14102242 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Seo, Sun-Hwa Joe, Ara Han, Hyo-Won Manivasagan, Panchanathan Jang, Eue-Soon Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title | Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title_full | Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title_fullStr | Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title_full_unstemmed | Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title_short | Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy |
title_sort | methylene blue-loaded mesoporous silica-coated gold nanorods on graphene oxide for synergistic photothermal and photodynamic therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612258/ https://www.ncbi.nlm.nih.gov/pubmed/36297675 http://dx.doi.org/10.3390/pharmaceutics14102242 |
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