Cargando…
Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells
Herpes Simplex Virus 1 (HSV-1) is a neurotropic human virus that belongs to the Alphaherpesvirinae subfamily of Herpesviridae. Establishment of its productive infection and progression of disease pathologies depend largely on successful release of virions from the virus-producing cells. HSV-1 is kno...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612286/ https://www.ncbi.nlm.nih.gov/pubmed/36298711 http://dx.doi.org/10.3390/v14102156 |
_version_ | 1784819737476202496 |
---|---|
author | Sharma, Pankaj Kapoor, Divya Shukla, Deepak |
author_facet | Sharma, Pankaj Kapoor, Divya Shukla, Deepak |
author_sort | Sharma, Pankaj |
collection | PubMed |
description | Herpes Simplex Virus 1 (HSV-1) is a neurotropic human virus that belongs to the Alphaherpesvirinae subfamily of Herpesviridae. Establishment of its productive infection and progression of disease pathologies depend largely on successful release of virions from the virus-producing cells. HSV-1 is known to exploit many host factors for its release. Recent studies have shown that heparanase (HPSE) is one such host enzyme that is recruited for this purpose. It is an endoglycosidase that cleaves heparan sulfate (HS) from the surface of infected cells. HS is a virus attachment coreceptor that is commonly found on cell surfaces as HS proteoglycans e.g., syndecan-1 (SDC-1). The current model suggests that HSV-1 during the late stage of infection upregulates HPSE, which in turn enhances viral release by removing the virus-trapping HS moieties. In addition to its role in directly enabling viral release, HPSE accelerates the shedding of HS-containing ectodomains of SDC-1, which enhances HSV-1 release via a similar mechanism by upregulating CREB3 and COPII proteins. This review outlines the role of HPSE and SDC-1 as newly assigned host factors that facilitate HSV-1 release during a lytic infection cycle. |
format | Online Article Text |
id | pubmed-9612286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96122862022-10-28 Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells Sharma, Pankaj Kapoor, Divya Shukla, Deepak Viruses Review Herpes Simplex Virus 1 (HSV-1) is a neurotropic human virus that belongs to the Alphaherpesvirinae subfamily of Herpesviridae. Establishment of its productive infection and progression of disease pathologies depend largely on successful release of virions from the virus-producing cells. HSV-1 is known to exploit many host factors for its release. Recent studies have shown that heparanase (HPSE) is one such host enzyme that is recruited for this purpose. It is an endoglycosidase that cleaves heparan sulfate (HS) from the surface of infected cells. HS is a virus attachment coreceptor that is commonly found on cell surfaces as HS proteoglycans e.g., syndecan-1 (SDC-1). The current model suggests that HSV-1 during the late stage of infection upregulates HPSE, which in turn enhances viral release by removing the virus-trapping HS moieties. In addition to its role in directly enabling viral release, HPSE accelerates the shedding of HS-containing ectodomains of SDC-1, which enhances HSV-1 release via a similar mechanism by upregulating CREB3 and COPII proteins. This review outlines the role of HPSE and SDC-1 as newly assigned host factors that facilitate HSV-1 release during a lytic infection cycle. MDPI 2022-09-30 /pmc/articles/PMC9612286/ /pubmed/36298711 http://dx.doi.org/10.3390/v14102156 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sharma, Pankaj Kapoor, Divya Shukla, Deepak Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title | Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title_full | Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title_fullStr | Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title_full_unstemmed | Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title_short | Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells |
title_sort | role of heparanase and syndecan-1 in hsv-1 release from infected cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612286/ https://www.ncbi.nlm.nih.gov/pubmed/36298711 http://dx.doi.org/10.3390/v14102156 |
work_keys_str_mv | AT sharmapankaj roleofheparanaseandsyndecan1inhsv1releasefrominfectedcells AT kapoordivya roleofheparanaseandsyndecan1inhsv1releasefrominfectedcells AT shukladeepak roleofheparanaseandsyndecan1inhsv1releasefrominfectedcells |