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Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU

Background: Platelet-to-lymphocyte ratio (PLR) is reported to be related to the outcome of intensive care unit (ICU) patients. However, little is known about their associations with prognosis in newborn patients in neonatal ICU (NICU). The aim of the present study was to investigate the prognostic s...

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Autores principales: Tang, Yanfei, Teng, Yiqun, Xu, Lingyan, Xu, Guangtao, Chen, Deqing, Jin, Xin, Li, Wanlu, Jin, Xiuhui, Zhu, Wen, Hu, Bo, Shen, Ruilin, Zhu, Yuzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612288/
https://www.ncbi.nlm.nih.gov/pubmed/36295557
http://dx.doi.org/10.3390/medicina58101397
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author Tang, Yanfei
Teng, Yiqun
Xu, Lingyan
Xu, Guangtao
Chen, Deqing
Jin, Xin
Li, Wanlu
Jin, Xiuhui
Zhu, Wen
Hu, Bo
Shen, Ruilin
Zhu, Yuzhang
author_facet Tang, Yanfei
Teng, Yiqun
Xu, Lingyan
Xu, Guangtao
Chen, Deqing
Jin, Xin
Li, Wanlu
Jin, Xiuhui
Zhu, Wen
Hu, Bo
Shen, Ruilin
Zhu, Yuzhang
author_sort Tang, Yanfei
collection PubMed
description Background: Platelet-to-lymphocyte ratio (PLR) is reported to be related to the outcome of intensive care unit (ICU) patients. However, little is known about their associations with prognosis in newborn patients in neonatal ICU (NICU). The aim of the present study was to investigate the prognostic significance of the PLR for newborn patients in the NICU. Methods: Data on newborn patients in the NICU were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC III) database. The initial PLR value of blood examinations within 24 h was analyzed. Spearman's correlation was used to analyze the association of PLR with the length of hospital and ICU stays. The chi-square test was used to analyze the association of PLR with mortality rate. Multivariable logistic regression was used to determine whether the PLR was an independent prognostic factor of mortality. The area under the receiver operating characteristic (ROC) curve was used to assess the predictive ability of models combining PLR with other variables. Results: In total, 5240 patients were enrolled. PLR was negatively associated with length of hospital stay and ICU stay (hospital stay: ρ = −0.416, p < 0.0001; ICU stay: ρ = −0.442, p < 0.0001). PLR was significantly correlated with hospital mortality (p < 0.0001). Lower PLR was associated with higher hospital mortality (OR = 0.85, 95% CI = 0.75–0.95, p = 0.005) and 90-day mortality (OR = 0.85, 95% CI = 0.76–0.96, p = 0.010). The prognostic predictive ability of models combining PLR with other variables for hospital mortality was good (AUC for Model 1 = 0.804, 95% CI = 0.73–0.88, p < 0.0001; AUC for Model 2 = 0.964, 95% CI = 0.95–0.98, p < 0.0001). Conclusion: PLR is a novel independent risk factor for newborn patients in the NICU.
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spelling pubmed-96122882022-10-28 Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU Tang, Yanfei Teng, Yiqun Xu, Lingyan Xu, Guangtao Chen, Deqing Jin, Xin Li, Wanlu Jin, Xiuhui Zhu, Wen Hu, Bo Shen, Ruilin Zhu, Yuzhang Medicina (Kaunas) Article Background: Platelet-to-lymphocyte ratio (PLR) is reported to be related to the outcome of intensive care unit (ICU) patients. However, little is known about their associations with prognosis in newborn patients in neonatal ICU (NICU). The aim of the present study was to investigate the prognostic significance of the PLR for newborn patients in the NICU. Methods: Data on newborn patients in the NICU were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC III) database. The initial PLR value of blood examinations within 24 h was analyzed. Spearman's correlation was used to analyze the association of PLR with the length of hospital and ICU stays. The chi-square test was used to analyze the association of PLR with mortality rate. Multivariable logistic regression was used to determine whether the PLR was an independent prognostic factor of mortality. The area under the receiver operating characteristic (ROC) curve was used to assess the predictive ability of models combining PLR with other variables. Results: In total, 5240 patients were enrolled. PLR was negatively associated with length of hospital stay and ICU stay (hospital stay: ρ = −0.416, p < 0.0001; ICU stay: ρ = −0.442, p < 0.0001). PLR was significantly correlated with hospital mortality (p < 0.0001). Lower PLR was associated with higher hospital mortality (OR = 0.85, 95% CI = 0.75–0.95, p = 0.005) and 90-day mortality (OR = 0.85, 95% CI = 0.76–0.96, p = 0.010). The prognostic predictive ability of models combining PLR with other variables for hospital mortality was good (AUC for Model 1 = 0.804, 95% CI = 0.73–0.88, p < 0.0001; AUC for Model 2 = 0.964, 95% CI = 0.95–0.98, p < 0.0001). Conclusion: PLR is a novel independent risk factor for newborn patients in the NICU. MDPI 2022-10-06 /pmc/articles/PMC9612288/ /pubmed/36295557 http://dx.doi.org/10.3390/medicina58101397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tang, Yanfei
Teng, Yiqun
Xu, Lingyan
Xu, Guangtao
Chen, Deqing
Jin, Xin
Li, Wanlu
Jin, Xiuhui
Zhu, Wen
Hu, Bo
Shen, Ruilin
Zhu, Yuzhang
Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title_full Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title_fullStr Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title_full_unstemmed Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title_short Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU
title_sort lower platelet-to-lymphocyte ratio was associated with poor prognosis for newborn patients in nicu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612288/
https://www.ncbi.nlm.nih.gov/pubmed/36295557
http://dx.doi.org/10.3390/medicina58101397
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