Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies

RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb su...

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Autores principales: Ramaswamy, Kavitha, Rashid, Mariya, Ramasamy, Selvarajan, Jayavelu, Tamilselvan, Venkataraman, Sangita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612308/
https://www.ncbi.nlm.nih.gov/pubmed/36298755
http://dx.doi.org/10.3390/v14102200
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author Ramaswamy, Kavitha
Rashid, Mariya
Ramasamy, Selvarajan
Jayavelu, Tamilselvan
Venkataraman, Sangita
author_facet Ramaswamy, Kavitha
Rashid, Mariya
Ramasamy, Selvarajan
Jayavelu, Tamilselvan
Venkataraman, Sangita
author_sort Ramaswamy, Kavitha
collection PubMed
description RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors.
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spelling pubmed-96123082022-10-28 Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies Ramaswamy, Kavitha Rashid, Mariya Ramasamy, Selvarajan Jayavelu, Tamilselvan Venkataraman, Sangita Viruses Review RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors. MDPI 2022-10-06 /pmc/articles/PMC9612308/ /pubmed/36298755 http://dx.doi.org/10.3390/v14102200 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramaswamy, Kavitha
Rashid, Mariya
Ramasamy, Selvarajan
Jayavelu, Tamilselvan
Venkataraman, Sangita
Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title_full Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title_fullStr Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title_full_unstemmed Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title_short Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies
title_sort revisiting viral rna-dependent rna polymerases: insights from recent structural studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612308/
https://www.ncbi.nlm.nih.gov/pubmed/36298755
http://dx.doi.org/10.3390/v14102200
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