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Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties

Plant-derived natural bioactive molecules are of great therapeutic potential but, so far, their application in nanomedicine has scarcely been studied. This work aimed at comparing two methodologies, i.e., adsorption and in situ incorporation, to prepare hybrid polyphenol/hydroxyapatite nanoparticles...

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Detalles Bibliográficos
Autores principales: Palierse, Estelle, Masse, Sylvie, Laurent, Guillaume, Le Griel, Patrick, Mosser, Gervaise, Coradin, Thibaud, Jolivalt, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612319/
https://www.ncbi.nlm.nih.gov/pubmed/36296776
http://dx.doi.org/10.3390/nano12203588
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author Palierse, Estelle
Masse, Sylvie
Laurent, Guillaume
Le Griel, Patrick
Mosser, Gervaise
Coradin, Thibaud
Jolivalt, Claude
author_facet Palierse, Estelle
Masse, Sylvie
Laurent, Guillaume
Le Griel, Patrick
Mosser, Gervaise
Coradin, Thibaud
Jolivalt, Claude
author_sort Palierse, Estelle
collection PubMed
description Plant-derived natural bioactive molecules are of great therapeutic potential but, so far, their application in nanomedicine has scarcely been studied. This work aimed at comparing two methodologies, i.e., adsorption and in situ incorporation, to prepare hybrid polyphenol/hydroxyapatite nanoparticles. Two flavonoids, baicalin and its aglycone derivative baicalein, and two phenolic acids derived from caffeic acid, rosmarinic and chlorogenic acids, were studied. Adsorption of these polyphenols on pre-formed hydroxyapatite nanoparticles did not modify particle size or shape and loading was less than 10% (w/w). In contrast, presence of polyphenols during the synthesis of nanoparticles significantly impacted and sometimes fully inhibited hydroxyapatite formation but recovered particles could exhibit higher loadings. For most hybrid particles, release profiles consisted of a 24 h burst effect followed by a slow release over 2 weeks. Antioxidant properties of the polyphenols were preserved after adsorption but not when incorporated in situ. These results provide fruitful clues for the valorization of natural bioactive molecules in nanomedicine.
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spelling pubmed-96123192022-10-28 Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties Palierse, Estelle Masse, Sylvie Laurent, Guillaume Le Griel, Patrick Mosser, Gervaise Coradin, Thibaud Jolivalt, Claude Nanomaterials (Basel) Article Plant-derived natural bioactive molecules are of great therapeutic potential but, so far, their application in nanomedicine has scarcely been studied. This work aimed at comparing two methodologies, i.e., adsorption and in situ incorporation, to prepare hybrid polyphenol/hydroxyapatite nanoparticles. Two flavonoids, baicalin and its aglycone derivative baicalein, and two phenolic acids derived from caffeic acid, rosmarinic and chlorogenic acids, were studied. Adsorption of these polyphenols on pre-formed hydroxyapatite nanoparticles did not modify particle size or shape and loading was less than 10% (w/w). In contrast, presence of polyphenols during the synthesis of nanoparticles significantly impacted and sometimes fully inhibited hydroxyapatite formation but recovered particles could exhibit higher loadings. For most hybrid particles, release profiles consisted of a 24 h burst effect followed by a slow release over 2 weeks. Antioxidant properties of the polyphenols were preserved after adsorption but not when incorporated in situ. These results provide fruitful clues for the valorization of natural bioactive molecules in nanomedicine. MDPI 2022-10-13 /pmc/articles/PMC9612319/ /pubmed/36296776 http://dx.doi.org/10.3390/nano12203588 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palierse, Estelle
Masse, Sylvie
Laurent, Guillaume
Le Griel, Patrick
Mosser, Gervaise
Coradin, Thibaud
Jolivalt, Claude
Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title_full Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title_fullStr Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title_full_unstemmed Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title_short Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties
title_sort synthesis of hybrid polyphenol/hydroxyapatite nanomaterials with anti-radical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612319/
https://www.ncbi.nlm.nih.gov/pubmed/36296776
http://dx.doi.org/10.3390/nano12203588
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