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COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?

Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian instit...

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Autores principales: Dona’, Daniele, Montagnani, Carlotta, Di Chiara, Costanza, Venturini, Elisabetta, Galli, Luisa, Lo Vecchio, Andrea, Denina, Marco, Olivini, Nicole, Bruzzese, Eugenia, Campana, Andrea, Giacchero, Roberta, Salvini, Filippo, Meini, Antonella, Ponzoni, Matteo, Trapani, Sandra, Rossi, Elena, Lombardi, Mary Haywood, Badolato, Raffaele, Pierri, Luca, Pruccoli, Giulia, Rossin, Sara, Colomba, Claudia, Cazzato, Salvatore, Pacati, Ilaria, Nicolini, Giangiacomo, Pierantoni, Luca, Bianchini, Sonia, Krzysztofiak, Andrzej, Garazzino, Silvia, Giaquinto, Carlo, Castelli Gattinara, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612333/
https://www.ncbi.nlm.nih.gov/pubmed/36298812
http://dx.doi.org/10.3390/v14102256
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author Dona’, Daniele
Montagnani, Carlotta
Di Chiara, Costanza
Venturini, Elisabetta
Galli, Luisa
Lo Vecchio, Andrea
Denina, Marco
Olivini, Nicole
Bruzzese, Eugenia
Campana, Andrea
Giacchero, Roberta
Salvini, Filippo
Meini, Antonella
Ponzoni, Matteo
Trapani, Sandra
Rossi, Elena
Lombardi, Mary Haywood
Badolato, Raffaele
Pierri, Luca
Pruccoli, Giulia
Rossin, Sara
Colomba, Claudia
Cazzato, Salvatore
Pacati, Ilaria
Nicolini, Giangiacomo
Pierantoni, Luca
Bianchini, Sonia
Krzysztofiak, Andrzej
Garazzino, Silvia
Giaquinto, Carlo
Castelli Gattinara, Guido
author_facet Dona’, Daniele
Montagnani, Carlotta
Di Chiara, Costanza
Venturini, Elisabetta
Galli, Luisa
Lo Vecchio, Andrea
Denina, Marco
Olivini, Nicole
Bruzzese, Eugenia
Campana, Andrea
Giacchero, Roberta
Salvini, Filippo
Meini, Antonella
Ponzoni, Matteo
Trapani, Sandra
Rossi, Elena
Lombardi, Mary Haywood
Badolato, Raffaele
Pierri, Luca
Pruccoli, Giulia
Rossin, Sara
Colomba, Claudia
Cazzato, Salvatore
Pacati, Ilaria
Nicolini, Giangiacomo
Pierantoni, Luca
Bianchini, Sonia
Krzysztofiak, Andrzej
Garazzino, Silvia
Giaquinto, Carlo
Castelli Gattinara, Guido
author_sort Dona’, Daniele
collection PubMed
description Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored as mild/moderate or severe/critical following the classification reported in the literature by Venturini, Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, we stratified all enrolled patients developing a posteriori severity score based on clinical presentation and outcomes and then compared all different scores analyzed. Results: We included 216 infants below 90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, and gastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale’s severity scores, 18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlation analysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini (R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed. Conclusions: The percentage of infants with severe COVID-19 varies widely according to the score systems. A unique clinical score should be designed for neonates and infants with COVID-19.
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spelling pubmed-96123332022-10-28 COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? Dona’, Daniele Montagnani, Carlotta Di Chiara, Costanza Venturini, Elisabetta Galli, Luisa Lo Vecchio, Andrea Denina, Marco Olivini, Nicole Bruzzese, Eugenia Campana, Andrea Giacchero, Roberta Salvini, Filippo Meini, Antonella Ponzoni, Matteo Trapani, Sandra Rossi, Elena Lombardi, Mary Haywood Badolato, Raffaele Pierri, Luca Pruccoli, Giulia Rossin, Sara Colomba, Claudia Cazzato, Salvatore Pacati, Ilaria Nicolini, Giangiacomo Pierantoni, Luca Bianchini, Sonia Krzysztofiak, Andrzej Garazzino, Silvia Giaquinto, Carlo Castelli Gattinara, Guido Viruses Article Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored as mild/moderate or severe/critical following the classification reported in the literature by Venturini, Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, we stratified all enrolled patients developing a posteriori severity score based on clinical presentation and outcomes and then compared all different scores analyzed. Results: We included 216 infants below 90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, and gastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale’s severity scores, 18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlation analysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini (R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed. Conclusions: The percentage of infants with severe COVID-19 varies widely according to the score systems. A unique clinical score should be designed for neonates and infants with COVID-19. MDPI 2022-10-14 /pmc/articles/PMC9612333/ /pubmed/36298812 http://dx.doi.org/10.3390/v14102256 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dona’, Daniele
Montagnani, Carlotta
Di Chiara, Costanza
Venturini, Elisabetta
Galli, Luisa
Lo Vecchio, Andrea
Denina, Marco
Olivini, Nicole
Bruzzese, Eugenia
Campana, Andrea
Giacchero, Roberta
Salvini, Filippo
Meini, Antonella
Ponzoni, Matteo
Trapani, Sandra
Rossi, Elena
Lombardi, Mary Haywood
Badolato, Raffaele
Pierri, Luca
Pruccoli, Giulia
Rossin, Sara
Colomba, Claudia
Cazzato, Salvatore
Pacati, Ilaria
Nicolini, Giangiacomo
Pierantoni, Luca
Bianchini, Sonia
Krzysztofiak, Andrzej
Garazzino, Silvia
Giaquinto, Carlo
Castelli Gattinara, Guido
COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title_full COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title_fullStr COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title_full_unstemmed COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title_short COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
title_sort covid-19 in infants less than 3 months: severe or not severe disease?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612333/
https://www.ncbi.nlm.nih.gov/pubmed/36298812
http://dx.doi.org/10.3390/v14102256
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