Cargando…
COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease?
Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian instit...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612333/ https://www.ncbi.nlm.nih.gov/pubmed/36298812 http://dx.doi.org/10.3390/v14102256 |
_version_ | 1784819748846960640 |
---|---|
author | Dona’, Daniele Montagnani, Carlotta Di Chiara, Costanza Venturini, Elisabetta Galli, Luisa Lo Vecchio, Andrea Denina, Marco Olivini, Nicole Bruzzese, Eugenia Campana, Andrea Giacchero, Roberta Salvini, Filippo Meini, Antonella Ponzoni, Matteo Trapani, Sandra Rossi, Elena Lombardi, Mary Haywood Badolato, Raffaele Pierri, Luca Pruccoli, Giulia Rossin, Sara Colomba, Claudia Cazzato, Salvatore Pacati, Ilaria Nicolini, Giangiacomo Pierantoni, Luca Bianchini, Sonia Krzysztofiak, Andrzej Garazzino, Silvia Giaquinto, Carlo Castelli Gattinara, Guido |
author_facet | Dona’, Daniele Montagnani, Carlotta Di Chiara, Costanza Venturini, Elisabetta Galli, Luisa Lo Vecchio, Andrea Denina, Marco Olivini, Nicole Bruzzese, Eugenia Campana, Andrea Giacchero, Roberta Salvini, Filippo Meini, Antonella Ponzoni, Matteo Trapani, Sandra Rossi, Elena Lombardi, Mary Haywood Badolato, Raffaele Pierri, Luca Pruccoli, Giulia Rossin, Sara Colomba, Claudia Cazzato, Salvatore Pacati, Ilaria Nicolini, Giangiacomo Pierantoni, Luca Bianchini, Sonia Krzysztofiak, Andrzej Garazzino, Silvia Giaquinto, Carlo Castelli Gattinara, Guido |
author_sort | Dona’, Daniele |
collection | PubMed |
description | Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored as mild/moderate or severe/critical following the classification reported in the literature by Venturini, Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, we stratified all enrolled patients developing a posteriori severity score based on clinical presentation and outcomes and then compared all different scores analyzed. Results: We included 216 infants below 90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, and gastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale’s severity scores, 18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlation analysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini (R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed. Conclusions: The percentage of infants with severe COVID-19 varies widely according to the score systems. A unique clinical score should be designed for neonates and infants with COVID-19. |
format | Online Article Text |
id | pubmed-9612333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96123332022-10-28 COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? Dona’, Daniele Montagnani, Carlotta Di Chiara, Costanza Venturini, Elisabetta Galli, Luisa Lo Vecchio, Andrea Denina, Marco Olivini, Nicole Bruzzese, Eugenia Campana, Andrea Giacchero, Roberta Salvini, Filippo Meini, Antonella Ponzoni, Matteo Trapani, Sandra Rossi, Elena Lombardi, Mary Haywood Badolato, Raffaele Pierri, Luca Pruccoli, Giulia Rossin, Sara Colomba, Claudia Cazzato, Salvatore Pacati, Ilaria Nicolini, Giangiacomo Pierantoni, Luca Bianchini, Sonia Krzysztofiak, Andrzej Garazzino, Silvia Giaquinto, Carlo Castelli Gattinara, Guido Viruses Article Compared to adults, severe or fatal COVID-19 disease is much less common in children. However, a higher risk for progression has been reported in infants. Different pediatric COVID-19 severity scores are reported in the literature. Methods: Subjects under 90 days of age admitted to 35 Italian institutions for COVID-19 were included. The severity of COVID-19 was scored as mild/moderate or severe/critical following the classification reported in the literature by Venturini, Dong, Kanburoglu, and Gale. To assess the diagnostic accuracy of each classification system, we stratified all enrolled patients developing a posteriori severity score based on clinical presentation and outcomes and then compared all different scores analyzed. Results: We included 216 infants below 90 days of age. The most common symptom was fever, followed by coryza, poor feeding, cough, and gastrointestinal manifestations. According to Venturini, Dong, Kanburoglu, and Gale’s severity scores, 18%, 6%, 4.2%, and 29.6% of infants presented with severe/critical disease, respectively. A correlation analysis between these four scores and the a posteriori severity score assigned to all enrolled subjects was performed, and a crescent strength of correlation from Gale (R = 0.355, p < 0.001) to Venturini (R = 0.425, p < 0.001), Dong (R = 0.734, p < 0.001), and Kanburoglu (R = 0.859, p < 0.001) was observed. Conclusions: The percentage of infants with severe COVID-19 varies widely according to the score systems. A unique clinical score should be designed for neonates and infants with COVID-19. MDPI 2022-10-14 /pmc/articles/PMC9612333/ /pubmed/36298812 http://dx.doi.org/10.3390/v14102256 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dona’, Daniele Montagnani, Carlotta Di Chiara, Costanza Venturini, Elisabetta Galli, Luisa Lo Vecchio, Andrea Denina, Marco Olivini, Nicole Bruzzese, Eugenia Campana, Andrea Giacchero, Roberta Salvini, Filippo Meini, Antonella Ponzoni, Matteo Trapani, Sandra Rossi, Elena Lombardi, Mary Haywood Badolato, Raffaele Pierri, Luca Pruccoli, Giulia Rossin, Sara Colomba, Claudia Cazzato, Salvatore Pacati, Ilaria Nicolini, Giangiacomo Pierantoni, Luca Bianchini, Sonia Krzysztofiak, Andrzej Garazzino, Silvia Giaquinto, Carlo Castelli Gattinara, Guido COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title | COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title_full | COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title_fullStr | COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title_full_unstemmed | COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title_short | COVID-19 in Infants Less than 3 Months: Severe or Not Severe Disease? |
title_sort | covid-19 in infants less than 3 months: severe or not severe disease? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612333/ https://www.ncbi.nlm.nih.gov/pubmed/36298812 http://dx.doi.org/10.3390/v14102256 |
work_keys_str_mv | AT donadaniele covid19ininfantslessthan3monthssevereornotseveredisease AT montagnanicarlotta covid19ininfantslessthan3monthssevereornotseveredisease AT dichiaracostanza covid19ininfantslessthan3monthssevereornotseveredisease AT venturinielisabetta covid19ininfantslessthan3monthssevereornotseveredisease AT galliluisa covid19ininfantslessthan3monthssevereornotseveredisease AT lovecchioandrea covid19ininfantslessthan3monthssevereornotseveredisease AT deninamarco covid19ininfantslessthan3monthssevereornotseveredisease AT olivininicole covid19ininfantslessthan3monthssevereornotseveredisease AT bruzzeseeugenia covid19ininfantslessthan3monthssevereornotseveredisease AT campanaandrea covid19ininfantslessthan3monthssevereornotseveredisease AT giaccheroroberta covid19ininfantslessthan3monthssevereornotseveredisease AT salvinifilippo covid19ininfantslessthan3monthssevereornotseveredisease AT meiniantonella covid19ininfantslessthan3monthssevereornotseveredisease AT ponzonimatteo covid19ininfantslessthan3monthssevereornotseveredisease AT trapanisandra covid19ininfantslessthan3monthssevereornotseveredisease AT rossielena covid19ininfantslessthan3monthssevereornotseveredisease AT lombardimaryhaywood covid19ininfantslessthan3monthssevereornotseveredisease AT badolatoraffaele covid19ininfantslessthan3monthssevereornotseveredisease AT pierriluca covid19ininfantslessthan3monthssevereornotseveredisease AT pruccoligiulia covid19ininfantslessthan3monthssevereornotseveredisease AT rossinsara covid19ininfantslessthan3monthssevereornotseveredisease AT colombaclaudia covid19ininfantslessthan3monthssevereornotseveredisease AT cazzatosalvatore covid19ininfantslessthan3monthssevereornotseveredisease AT pacatiilaria covid19ininfantslessthan3monthssevereornotseveredisease AT nicolinigiangiacomo covid19ininfantslessthan3monthssevereornotseveredisease AT pierantoniluca covid19ininfantslessthan3monthssevereornotseveredisease AT bianchinisonia covid19ininfantslessthan3monthssevereornotseveredisease AT krzysztofiakandrzej covid19ininfantslessthan3monthssevereornotseveredisease AT garazzinosilvia covid19ininfantslessthan3monthssevereornotseveredisease AT giaquintocarlo covid19ininfantslessthan3monthssevereornotseveredisease AT castelligattinaraguido covid19ininfantslessthan3monthssevereornotseveredisease AT covid19ininfantslessthan3monthssevereornotseveredisease |