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Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property

Soft actuators have attracted extensive attention for promising applications in drug delivery, microfluidic switches, artificial muscles and flexible sensors. However, the performance of pH-responsive hydrogel actuators, such as regarding reversible bending property and adhesive property, remains to...

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Autores principales: Jiang, Shulan, Xia, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612346/
https://www.ncbi.nlm.nih.gov/pubmed/36298003
http://dx.doi.org/10.3390/polym14204425
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author Jiang, Shulan
Xia, Li
author_facet Jiang, Shulan
Xia, Li
author_sort Jiang, Shulan
collection PubMed
description Soft actuators have attracted extensive attention for promising applications in drug delivery, microfluidic switches, artificial muscles and flexible sensors. However, the performance of pH-responsive hydrogel actuators, such as regarding reversible bending property and adhesive property, remains to be improved. In this study, inspired by drosera leaves, we have fabricated high-performance bilayer, pH-responsive poly(acrylamide-acrylic acid-3-acrylamidophenylboronic acid)(P(AAm-AAc-3-AAPBA)) based on the copolymers of AAm, AAc and 3-AAPBA. The pH-sensitive actuators were fabricated by ultraviolet polymerization of the P(AAm-AAc-3-AAPBA) layer as the active actuating layer and the PAAm layer as the auxiliary actuating layer. The effects of pH, glucose concentration and content of 3-AAPBA on bending behavior of P(AAm-AAc-3-AAPBA)/PAAm bilayer actuators were discussed. By tuning the pH of media, the soft actuator could achieve fast and large-amplitude bidirectional bending behaviors. The bending orientation and bending degree can be reversibly and precisely adjusted. More importantly, P(AAm-AAc-3-AAPBA) hydrogel shows good adhesive property in polyvinyl alcohol (PVA) solution; thus, complex structures have been fabricated. In addition, the bilayer hydrogel structures have been demonstrated as soft actuators, bionic flowers and bionic manipulators. The proposed pH-responsive bilayer actuator shows great potential for drug delivery and other medical systems.
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spelling pubmed-96123462022-10-28 Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property Jiang, Shulan Xia, Li Polymers (Basel) Article Soft actuators have attracted extensive attention for promising applications in drug delivery, microfluidic switches, artificial muscles and flexible sensors. However, the performance of pH-responsive hydrogel actuators, such as regarding reversible bending property and adhesive property, remains to be improved. In this study, inspired by drosera leaves, we have fabricated high-performance bilayer, pH-responsive poly(acrylamide-acrylic acid-3-acrylamidophenylboronic acid)(P(AAm-AAc-3-AAPBA)) based on the copolymers of AAm, AAc and 3-AAPBA. The pH-sensitive actuators were fabricated by ultraviolet polymerization of the P(AAm-AAc-3-AAPBA) layer as the active actuating layer and the PAAm layer as the auxiliary actuating layer. The effects of pH, glucose concentration and content of 3-AAPBA on bending behavior of P(AAm-AAc-3-AAPBA)/PAAm bilayer actuators were discussed. By tuning the pH of media, the soft actuator could achieve fast and large-amplitude bidirectional bending behaviors. The bending orientation and bending degree can be reversibly and precisely adjusted. More importantly, P(AAm-AAc-3-AAPBA) hydrogel shows good adhesive property in polyvinyl alcohol (PVA) solution; thus, complex structures have been fabricated. In addition, the bilayer hydrogel structures have been demonstrated as soft actuators, bionic flowers and bionic manipulators. The proposed pH-responsive bilayer actuator shows great potential for drug delivery and other medical systems. MDPI 2022-10-19 /pmc/articles/PMC9612346/ /pubmed/36298003 http://dx.doi.org/10.3390/polym14204425 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Shulan
Xia, Li
Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title_full Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title_fullStr Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title_full_unstemmed Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title_short Bioinspired High-Performance Bilayer, pH-Responsive Hydrogel with Superior Adhesive Property
title_sort bioinspired high-performance bilayer, ph-responsive hydrogel with superior adhesive property
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612346/
https://www.ncbi.nlm.nih.gov/pubmed/36298003
http://dx.doi.org/10.3390/polym14204425
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