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Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Tumor necrosis factor alpha (TNF-α) plays a vital role in Alzheimer’s disease (AD) pathology, and TNF-α inhibitors (TNFIs) modulate AD pathology. We fused the TNF-α receptor (TNFR), a biologic TNFI that sequesters TNF-α, to a transferrin receptor antibody (TfRMAb) to deliver the TNFI into the brain...

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Detalles Bibliográficos
Autores principales:	Ou, Weijun, Ohno, Yuu, Yang, Joshua, Chandrashekar, Devaraj V., Abdullah, Tamara, Sun, Jiahong, Murphy, Riley, Roules, Chuli, Jagadeesan, Nataraj, Cribbs, David H., Sumbria, Rachita K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612380/ https://www.ncbi.nlm.nih.gov/pubmed/36297637 http://dx.doi.org/10.3390/pharmaceutics14102200

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