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Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models

SARS-CoV-2 causes COVID-19, a predominantly pulmonary disease characterized by a burst of pro-inflammatory cytokines and an increase in free iron. The viral glycoprotein Spike mediates fusion to the host cell membrane, but its role as a virulence factor is largely unknown. Recently, the antiviral ac...

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Detalles Bibliográficos
Autores principales:	Cutone, Antimo, Rosa, Luigi, Bonaccorsi di Patti, Maria Carmela, Iacovelli, Federico, Conte, Maria Pia, Ianiro, Giusi, Romeo, Alice, Campione, Elena, Bianchi, Luca, Valenti, Piera, Falconi, Mattia, Musci, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612385/ https://www.ncbi.nlm.nih.gov/pubmed/36297546 http://dx.doi.org/10.3390/pharmaceutics14102111

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