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Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury
OBJECTIVE: To systematically assess white matter injury (WMI) in preterm infants with posthemorrhagic ventricular dilatation (PHVD) using a high-threshold intervention strategy. STUDY DESIGN: This retrospective analysis included 85 preterm infants (≤34 weeks of gestation) with grade 2–3 germinal mat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612444/ https://www.ncbi.nlm.nih.gov/pubmed/36301835 http://dx.doi.org/10.1371/journal.pone.0276446 |
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author | Valverde, Eva Ybarra, Marta Benito, Andrea V. Bravo, María Carmen Pellicer, Adelina |
author_facet | Valverde, Eva Ybarra, Marta Benito, Andrea V. Bravo, María Carmen Pellicer, Adelina |
author_sort | Valverde, Eva |
collection | PubMed |
description | OBJECTIVE: To systematically assess white matter injury (WMI) in preterm infants with posthemorrhagic ventricular dilatation (PHVD) using a high-threshold intervention strategy. STUDY DESIGN: This retrospective analysis included 85 preterm infants (≤34 weeks of gestation) with grade 2–3 germinal matrix-intraventricular hemorrhage. Cranial ultrasound (cUS) scans were assessed for WMI and ventricular width and shape. Forty-eight infants developed PHVD, 21 of whom (intervention group) underwent cerebrospinal fluid drainage according to a predefined threshold (ventricular index ≥p97+4 mm or anterior horn width >10 mm, and the presence of frontal horn ballooning). The other 27 infants underwent a conservative approach (non-intervention group). The two PHVD groups were compared regarding ventricular width at two stages: the worst cUS for the non-intervention group (scans showing the largest ventricular measurements) versus pre-intervention cUS in the intervention group, and at term equivalent age. WMI was classified as normal/mild, moderate and severe. RESULTS: The intervention group showed significantly larger ventricular index, anterior horn width and thalamo-occipital diameter than the non-intervention group at the two timepoints. Moderate and severe WMI were more frequent in the infants with PHVD (p<0.001), regardless of management (intervention or conservative management). There was a linear relationship between the severity of PHVD and WMI (p<0.001). CONCLUSIONS: Preterm infants with PHVD who undergo a high-threshold intervention strategy associate an increased risk of WMI. |
format | Online Article Text |
id | pubmed-9612444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96124442022-10-28 Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury Valverde, Eva Ybarra, Marta Benito, Andrea V. Bravo, María Carmen Pellicer, Adelina PLoS One Research Article OBJECTIVE: To systematically assess white matter injury (WMI) in preterm infants with posthemorrhagic ventricular dilatation (PHVD) using a high-threshold intervention strategy. STUDY DESIGN: This retrospective analysis included 85 preterm infants (≤34 weeks of gestation) with grade 2–3 germinal matrix-intraventricular hemorrhage. Cranial ultrasound (cUS) scans were assessed for WMI and ventricular width and shape. Forty-eight infants developed PHVD, 21 of whom (intervention group) underwent cerebrospinal fluid drainage according to a predefined threshold (ventricular index ≥p97+4 mm or anterior horn width >10 mm, and the presence of frontal horn ballooning). The other 27 infants underwent a conservative approach (non-intervention group). The two PHVD groups were compared regarding ventricular width at two stages: the worst cUS for the non-intervention group (scans showing the largest ventricular measurements) versus pre-intervention cUS in the intervention group, and at term equivalent age. WMI was classified as normal/mild, moderate and severe. RESULTS: The intervention group showed significantly larger ventricular index, anterior horn width and thalamo-occipital diameter than the non-intervention group at the two timepoints. Moderate and severe WMI were more frequent in the infants with PHVD (p<0.001), regardless of management (intervention or conservative management). There was a linear relationship between the severity of PHVD and WMI (p<0.001). CONCLUSIONS: Preterm infants with PHVD who undergo a high-threshold intervention strategy associate an increased risk of WMI. Public Library of Science 2022-10-27 /pmc/articles/PMC9612444/ /pubmed/36301835 http://dx.doi.org/10.1371/journal.pone.0276446 Text en © 2022 Valverde et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Valverde, Eva Ybarra, Marta Benito, Andrea V. Bravo, María Carmen Pellicer, Adelina Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title_full | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title_fullStr | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title_full_unstemmed | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title_short | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
title_sort | posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612444/ https://www.ncbi.nlm.nih.gov/pubmed/36301835 http://dx.doi.org/10.1371/journal.pone.0276446 |
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