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Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk”
In a published randomized controlled trial, household units were randomized to a nutrient bar supplementation group or a control condition, but the non-independence of observations within the same household (i.e., the clustering effect) was not accounted for in the statistical analyses. Therefore, w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612448/ https://www.ncbi.nlm.nih.gov/pubmed/36301862 http://dx.doi.org/10.1371/journal.pone.0275242 |
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author | Jamshidi-Naeini, Yasaman Golzarri-Arroyo, Lilian Vorland, Colby J. Brown, Andrew W. Dickinson, Stephanie Allison, David B. |
author_facet | Jamshidi-Naeini, Yasaman Golzarri-Arroyo, Lilian Vorland, Colby J. Brown, Andrew W. Dickinson, Stephanie Allison, David B. |
author_sort | Jamshidi-Naeini, Yasaman |
collection | PubMed |
description | In a published randomized controlled trial, household units were randomized to a nutrient bar supplementation group or a control condition, but the non-independence of observations within the same household (i.e., the clustering effect) was not accounted for in the statistical analyses. Therefore, we reanalyzed the data appropriately by adjusting degrees of freedom using the between-within method, and accounting for household units using linear mixed effect models with random intercepts for family units and subjects nested within family units for each reported outcome. Results from this reanalysis showed that ignoring the clustering and nesting effects in the original analyses had resulted in anticonservative (i.e., too small) time x group interaction p-values. Still, majority of the conclusions remained unchanged. |
format | Online Article Text |
id | pubmed-9612448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96124482022-10-28 Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” Jamshidi-Naeini, Yasaman Golzarri-Arroyo, Lilian Vorland, Colby J. Brown, Andrew W. Dickinson, Stephanie Allison, David B. PLoS One Research Article In a published randomized controlled trial, household units were randomized to a nutrient bar supplementation group or a control condition, but the non-independence of observations within the same household (i.e., the clustering effect) was not accounted for in the statistical analyses. Therefore, we reanalyzed the data appropriately by adjusting degrees of freedom using the between-within method, and accounting for household units using linear mixed effect models with random intercepts for family units and subjects nested within family units for each reported outcome. Results from this reanalysis showed that ignoring the clustering and nesting effects in the original analyses had resulted in anticonservative (i.e., too small) time x group interaction p-values. Still, majority of the conclusions remained unchanged. Public Library of Science 2022-10-27 /pmc/articles/PMC9612448/ /pubmed/36301862 http://dx.doi.org/10.1371/journal.pone.0275242 Text en © 2022 Jamshidi-Naeini et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jamshidi-Naeini, Yasaman Golzarri-Arroyo, Lilian Vorland, Colby J. Brown, Andrew W. Dickinson, Stephanie Allison, David B. Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title | Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title_full | Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title_fullStr | Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title_full_unstemmed | Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title_short | Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
title_sort | accounting for the clustering and nesting effects verifies most conclusions. corrected analysis of: “randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk” |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612448/ https://www.ncbi.nlm.nih.gov/pubmed/36301862 http://dx.doi.org/10.1371/journal.pone.0275242 |
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