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BOOME: A Python package for handling misclassified disease and ultrahigh-dimensional error-prone gene expression data

In gene expression data analysis framework, ultrahigh dimensionality and measurement error are ubiquitous features. Therefore, it is crucial to correct measurement error effects and make variable selection when fitting a regression model. In this paper, we introduce a python package BOOME, which ref...

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Detalles Bibliográficos
Autor principal: Chen, Li-Pang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612554/
https://www.ncbi.nlm.nih.gov/pubmed/36301828
http://dx.doi.org/10.1371/journal.pone.0276664
Descripción
Sumario:In gene expression data analysis framework, ultrahigh dimensionality and measurement error are ubiquitous features. Therefore, it is crucial to correct measurement error effects and make variable selection when fitting a regression model. In this paper, we introduce a python package BOOME, which refers to BOOsting algorithm for Measurement Error in binary responses and ultrahigh-dimensional predictors. We primarily focus on logistic regression and probit models with responses, predictors, or both contaminated with measurement error. The BOOME aims to address measurement error effects, and employ boosting procedure to make variable selection and estimation.