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Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases

OBJECTIVE: This study aimed to analyze the patient-reported outcomes and survival following surgical treatment of bone metastases from (uLMS) uterine leiomyosarcoma. METHODS: A retrospective review of six patients undergoing surgical procedures for metastatic uLMS over seven years was conducted at a...

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Autores principales: Öztürk Başarır, Zehra, Onur Karaca, Mustafa, Balaban, Kamil, Başarır, Kerem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Association of Orthopaedics and Traumatology, and Turkish Society of Orthopaedics and Traumatology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612665/
https://www.ncbi.nlm.nih.gov/pubmed/35968620
http://dx.doi.org/10.5152/j.aott.2022.22002
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author Öztürk Başarır, Zehra
Onur Karaca, Mustafa
Balaban, Kamil
Başarır, Kerem
author_facet Öztürk Başarır, Zehra
Onur Karaca, Mustafa
Balaban, Kamil
Başarır, Kerem
author_sort Öztürk Başarır, Zehra
collection PubMed
description OBJECTIVE: This study aimed to analyze the patient-reported outcomes and survival following surgical treatment of bone metastases from (uLMS) uterine leiomyosarcoma. METHODS: A retrospective review of six patients undergoing surgical procedures for metastatic uLMS over seven years was conducted at a single center. All patients were reviewed for their primary malignancy and characteristics of bone metastasis during follow-up. Clinical presentation of bone metastasis, modality, and the type of treatment related to musculoskeletal involvement were also analyzed. The visual analog pain scale (VAS) and Eastern Cooperative Oncology Group (ECOG) performance status scale were used pre-and postoperatively to evaluate the patient-reported outcome. RESULTS: Four patients had solitary bone metastases, whereas multiple bone metastases were diagnosed in two. Of those who had solitary bone metastasis, all of them were treated with wide resection. One of the two patients with multiple bone metastases was also treated with wide resection, and the other was treated with intralesional curettage. Four patients died from primary disease, and two were alive without evidence of disease recurrence. The median survival time following a diagnosis of bone metastasis was 15.0 months (95% CI, 0.6 to 29.4 months). The mean VAS scores for all six patients improved. However, the improvement in ECOG performance status was seen in only four patients. CONCLUSION: Although the prognosis of uLMS patients with bone metastasis seems poor, wide resection of the solitary bone metastasis may help prolong the overall survival. Performing orthopedic surgeries for the bone metastasis from uLMS in case of intractable pain after palliative radiotherapy, impending or pathological fracture, or solitary disease has been shown to decrease the pain significantly and improve the performance status in the majority. LEVEL OF EVIDENCE: Level IV, Therapeutic Study
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spelling pubmed-96126652022-11-04 Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases Öztürk Başarır, Zehra Onur Karaca, Mustafa Balaban, Kamil Başarır, Kerem Acta Orthop Traumatol Turc Research Article OBJECTIVE: This study aimed to analyze the patient-reported outcomes and survival following surgical treatment of bone metastases from (uLMS) uterine leiomyosarcoma. METHODS: A retrospective review of six patients undergoing surgical procedures for metastatic uLMS over seven years was conducted at a single center. All patients were reviewed for their primary malignancy and characteristics of bone metastasis during follow-up. Clinical presentation of bone metastasis, modality, and the type of treatment related to musculoskeletal involvement were also analyzed. The visual analog pain scale (VAS) and Eastern Cooperative Oncology Group (ECOG) performance status scale were used pre-and postoperatively to evaluate the patient-reported outcome. RESULTS: Four patients had solitary bone metastases, whereas multiple bone metastases were diagnosed in two. Of those who had solitary bone metastasis, all of them were treated with wide resection. One of the two patients with multiple bone metastases was also treated with wide resection, and the other was treated with intralesional curettage. Four patients died from primary disease, and two were alive without evidence of disease recurrence. The median survival time following a diagnosis of bone metastasis was 15.0 months (95% CI, 0.6 to 29.4 months). The mean VAS scores for all six patients improved. However, the improvement in ECOG performance status was seen in only four patients. CONCLUSION: Although the prognosis of uLMS patients with bone metastasis seems poor, wide resection of the solitary bone metastasis may help prolong the overall survival. Performing orthopedic surgeries for the bone metastasis from uLMS in case of intractable pain after palliative radiotherapy, impending or pathological fracture, or solitary disease has been shown to decrease the pain significantly and improve the performance status in the majority. LEVEL OF EVIDENCE: Level IV, Therapeutic Study Turkish Association of Orthopaedics and Traumatology, and Turkish Society of Orthopaedics and Traumatology 2022-07-01 /pmc/articles/PMC9612665/ /pubmed/35968620 http://dx.doi.org/10.5152/j.aott.2022.22002 Text en 2022 authors https://creativecommons.org/licenses/by-nc/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Öztürk Başarır, Zehra
Onur Karaca, Mustafa
Balaban, Kamil
Başarır, Kerem
Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title_full Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title_fullStr Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title_full_unstemmed Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title_short Clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: A report of 6 cases
title_sort clinical outcomes and survival following treatment of bone metastases from uterine leiomyosarcoma: a report of 6 cases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612665/
https://www.ncbi.nlm.nih.gov/pubmed/35968620
http://dx.doi.org/10.5152/j.aott.2022.22002
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