Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa

Dolutegravir 50 mg is registered for use in children weighing 20–40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in chil...

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Autores principales: Waalewijn, Hylke, Stol, Kim, van der Knaap, Linda, Fraaij, Pieter L.A., Vermont, Clementien, van Rossum, Annemarie M.C., Strik-Albers, Riet, Burger, David M., Svensson, Elin M., Colbers, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612713/
https://www.ncbi.nlm.nih.gov/pubmed/36111542
http://dx.doi.org/10.1097/QAD.0000000000003350
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author Waalewijn, Hylke
Stol, Kim
van der Knaap, Linda
Fraaij, Pieter L.A.
Vermont, Clementien
van Rossum, Annemarie M.C.
Strik-Albers, Riet
Burger, David M.
Svensson, Elin M.
Colbers, Angela
author_facet Waalewijn, Hylke
Stol, Kim
van der Knaap, Linda
Fraaij, Pieter L.A.
Vermont, Clementien
van Rossum, Annemarie M.C.
Strik-Albers, Riet
Burger, David M.
Svensson, Elin M.
Colbers, Angela
author_sort Waalewijn, Hylke
collection PubMed
description Dolutegravir 50 mg is registered for use in children weighing 20–40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.
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spelling pubmed-96127132022-11-04 Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa Waalewijn, Hylke Stol, Kim van der Knaap, Linda Fraaij, Pieter L.A. Vermont, Clementien van Rossum, Annemarie M.C. Strik-Albers, Riet Burger, David M. Svensson, Elin M. Colbers, Angela AIDS Research Letters Dolutegravir 50 mg is registered for use in children weighing 20–40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal. Lippincott Williams & Wilkins 2022-11-15 2022-09-15 /pmc/articles/PMC9612713/ /pubmed/36111542 http://dx.doi.org/10.1097/QAD.0000000000003350 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Letters
Waalewijn, Hylke
Stol, Kim
van der Knaap, Linda
Fraaij, Pieter L.A.
Vermont, Clementien
van Rossum, Annemarie M.C.
Strik-Albers, Riet
Burger, David M.
Svensson, Elin M.
Colbers, Angela
Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title_full Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title_fullStr Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title_full_unstemmed Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title_short Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa
title_sort adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-sahara africa
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612713/
https://www.ncbi.nlm.nih.gov/pubmed/36111542
http://dx.doi.org/10.1097/QAD.0000000000003350
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