IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis-aconitate to produce itaconate in the mitochondria. Itaconate serves as an immunomodulator of macrophages and represses inflammation in infectious diseases....

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Detalles Bibliográficos
Autores principales: Sun, Qingyu, Hu, Tingting, Zhang, Yurui, Wang, Xiaotong, Liu, Jing, Chen, Wen, Wei, Chao, Liu, Dianxin, Wu, Weihua, Lan, Ting, Ding, Yumeng, Luo, Zhaoli, Liu, Meng, Shen, Danmin, Xiao, Zhongnan, Hu, Liye, Pang, Miaoyi, Ma, Yiran, Shi, Lei, Wang, Peipei, Zhang, Jiannan, Li, Qian, Yang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612919/
https://www.ncbi.nlm.nih.gov/pubmed/36311727
http://dx.doi.org/10.3389/fimmu.2022.1012442

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