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Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes

BACKGROUND: There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD-TX), haemodialysis (TX-HD-TX) and preemptive deceased donor...

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Autores principales: Couceiro, Carlos, Rama, Inés, Comas, Jordi, Montero, Núria, Manonelles, Anna, Codina, Sergi, Favà, Alexandre, Melilli, Edoardo, Coloma, Ana, Quero, Maria, Tort, Jaume, Cruzado, Josep M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613432/
https://www.ncbi.nlm.nih.gov/pubmed/36325006
http://dx.doi.org/10.1093/ckj/sfac155
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author Couceiro, Carlos
Rama, Inés
Comas, Jordi
Montero, Núria
Manonelles, Anna
Codina, Sergi
Favà, Alexandre
Melilli, Edoardo
Coloma, Ana
Quero, Maria
Tort, Jaume
Cruzado, Josep M
author_facet Couceiro, Carlos
Rama, Inés
Comas, Jordi
Montero, Núria
Manonelles, Anna
Codina, Sergi
Favà, Alexandre
Melilli, Edoardo
Coloma, Ana
Quero, Maria
Tort, Jaume
Cruzado, Josep M
author_sort Couceiro, Carlos
collection PubMed
description BACKGROUND: There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD-TX), haemodialysis (TX-HD-TX) and preemptive deceased donor retransplantation (TX-TX) on patient survival and second KT outcomes. METHODS: A retrospective observational study from the Catalan Renal Registry was carried out. We included adult patients with failing of their first KT from 2000 to 2018. RESULTS: Among 2045 patients, 1829 started on HD (89.4%), 168 on PD (8.2%) and 48 (2.4%) received a preemptive KT. Non-inclusion on the KT waiting list and HD were associated with worse patient survival. For patients included on the waiting list, the probability of human leucocyte antigens (HLA) sensitization and to receive a second KT was similar in HD and PD. A total of 776 patients received a second KT (38%), 656 in TX-HD-TX, 72 in TX-PD-TX and 48 in TX-TX groups. Adjusted mortality after second KT was higher in TX-HD-TX patients compared with TX-TX and TX-PD-TX groups, without differences between TX-TX and TX-PD-TX groups. Death-censored second graft survival was similar in all three groups. CONCLUSIONS: Our results suggest that after first KT failure, PD is superior to HD in reducing mortality in candidates for a second KT without options for preemptive retransplantation.
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spelling pubmed-96134322022-11-01 Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes Couceiro, Carlos Rama, Inés Comas, Jordi Montero, Núria Manonelles, Anna Codina, Sergi Favà, Alexandre Melilli, Edoardo Coloma, Ana Quero, Maria Tort, Jaume Cruzado, Josep M Clin Kidney J Original Article BACKGROUND: There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD-TX), haemodialysis (TX-HD-TX) and preemptive deceased donor retransplantation (TX-TX) on patient survival and second KT outcomes. METHODS: A retrospective observational study from the Catalan Renal Registry was carried out. We included adult patients with failing of their first KT from 2000 to 2018. RESULTS: Among 2045 patients, 1829 started on HD (89.4%), 168 on PD (8.2%) and 48 (2.4%) received a preemptive KT. Non-inclusion on the KT waiting list and HD were associated with worse patient survival. For patients included on the waiting list, the probability of human leucocyte antigens (HLA) sensitization and to receive a second KT was similar in HD and PD. A total of 776 patients received a second KT (38%), 656 in TX-HD-TX, 72 in TX-PD-TX and 48 in TX-TX groups. Adjusted mortality after second KT was higher in TX-HD-TX patients compared with TX-TX and TX-PD-TX groups, without differences between TX-TX and TX-PD-TX groups. Death-censored second graft survival was similar in all three groups. CONCLUSIONS: Our results suggest that after first KT failure, PD is superior to HD in reducing mortality in candidates for a second KT without options for preemptive retransplantation. Oxford University Press 2022-06-14 /pmc/articles/PMC9613432/ /pubmed/36325006 http://dx.doi.org/10.1093/ckj/sfac155 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Couceiro, Carlos
Rama, Inés
Comas, Jordi
Montero, Núria
Manonelles, Anna
Codina, Sergi
Favà, Alexandre
Melilli, Edoardo
Coloma, Ana
Quero, Maria
Tort, Jaume
Cruzado, Josep M
Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title_full Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title_fullStr Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title_full_unstemmed Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title_short Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
title_sort effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613432/
https://www.ncbi.nlm.nih.gov/pubmed/36325006
http://dx.doi.org/10.1093/ckj/sfac155
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