A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure

Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment remains unknown. We performed multiomic (transcrip...

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Detalles Bibliográficos
Autores principales: Kutyna, Monika M., Kok, Chung Hoow, Lim, Yoon, Tran, Elizabeth Ngoc Hoa, Campbell, David, Paton, Sharon, Thompson-Peach, Chloe, Lim, Kelly, Cakouros, Dimitrios, Arthur, Agnes, Hughes, Timothy, Kumar, Sharad, Thomas, Daniel, Gronthos, Stan, Hiwase, Devendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613466/
https://www.ncbi.nlm.nih.gov/pubmed/36038666
http://dx.doi.org/10.1038/s41375-022-01686-y

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