CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery

Nucleophilic amino acids are important in covalent drug development yet underutilized as anti-microbial targets. Chemoproteomic technologies have been developed to mine chemically accessible residues via their intrinsic reactivity towards electrophilic probes but cannot discern which chemically reac...

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Detalles Bibliográficos
Autores principales: Benns, H. J., Storch, M., Falco, J. A., Fisher, F. R., Tamaki, F., Alves, E., Wincott, C. J., Milne, R., Wiedemar, N., Craven, G., Baragaña, B., Wyllie, S., Baum, J., Baldwin, G. S., Weerapana, E., Tate, E. W., Child, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613468/
https://www.ncbi.nlm.nih.gov/pubmed/36266336
http://dx.doi.org/10.1038/s41564-022-01249-y

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