Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice

Klebsiella spp. that secrete the DNA-alkylating enterotoxin tilimycin colonize the human intestinal tract. Numbers of toxigenic bacteria increase during antibiotic use, and the resulting accumulation of tilimycin in the intestinal lumen damages the epithelium via genetic instability and apoptosis. H...

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Detalles Bibliográficos
Autores principales: Kienesberger, Sabine, Cosic, Amar, Kitsera, Maksym, Raffl, Sandra, Hiesinger, Marlene, Leitner, Eva, Halwachs, Bettina, Gorkiewicz, Gregor, Glabonjat, Ronald A., Raber, Georg, Lembacher-Fadum, Christian, Breinbauer, Rolf, Schild, Stefan, Zechner, Ellen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613472/
https://www.ncbi.nlm.nih.gov/pubmed/36289400
http://dx.doi.org/10.1038/s41564-022-01260-3

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