Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults

Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and features of chromothriptic events in T-cell acute lymphoblastic leukemias (T-ALL). SNP array was performed in 103 T-A...

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Detalles Bibliográficos
Autores principales: Arniani, Silvia, Pierini, Valentina, Pellanera, Fabrizia, Matteucci, Caterina, Di Giacomo, Danika, Bardelli, Valentina, Quintini, Martina, Mavridou, Elena, Lema Fernandez, Anair Graciela, Nardelli, Carlotta, Moretti, Martina, Gorello, Paolo, Crescenzi, Barbara, Romoli, Silvia, Beacci, Donatella, Cerrano, Marco, Fracchiolla, Nicola, Sica, Simona, Forghieri, Fabio, Giglio, Fabio, Dargenio, Michela, Elia, Loredana, La Starza, Roberta, Mecucci, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613476/
https://www.ncbi.nlm.nih.gov/pubmed/35974102
http://dx.doi.org/10.1038/s41375-022-01671-5

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