GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation

Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental inflammatory and autoimmune diseases. Here we show that the adhesion molecule GPR97 allosterically activates CD177-associated...

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Detalles Bibliográficos
Autores principales: Chu, Tai-Ying, Zheng-Gérard, Céline, Huang, Kuan-Yeh, Chang, Yu-Chi, Chen, Ying-Wen, I, Kuan-Yu, Lo, Yu-Ling, Chiang, Nien-Yi, Chen, Hsin-Yi, Stacey, Martin, Gordon, Siamon, Tseng, Wen-Yi, Sun, Chiao-Yin, Wu, Yen-Mu, Pan, Yi-Shin, Huang, Chien-Hao, Lin, Chun-Yen, Chen, Tse-Ching, El Omari, Kamel, Antonelou, Marilina, Henderson, Scott R., Salama, Alan, Seiradake, Elena, Lin, Hsi-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613636/
https://www.ncbi.nlm.nih.gov/pubmed/36302784
http://dx.doi.org/10.1038/s41467-022-34083-1

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