Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote

Organophosphates (OPs) are inhibitors of acetylcholinesterase and have deleterious effects on the central nervous system. Clinical manifestations of OP poisoning include convulsions, which represent an underlying toxic neuro-pathological process, leading to permanent neuronal damage. This neurotoxic...

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Detalles Bibliográficos
Autores principales: Weitman, Michal, Eisenkraft, Arik, TaShma, Zeev, Makarovsky, Igor, Last, David, Daniels, Dianne, Guez, David, Shneor, Ran, Mardor, Yael, Nudelman, Abraham, Krivoy, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613653/
https://www.ncbi.nlm.nih.gov/pubmed/36302937
http://dx.doi.org/10.1038/s41598-022-23141-9

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