IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4(−/−) mice as prone to developing BCP-ALL with age. Irf4(−/−) preB-I cells exhibited impaired differentiation but enhanced prolife...

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Detalles Bibliográficos
Autores principales: Das Gupta, Dennis, Paul, Christoph, Samel, Nadine, Bieringer, Maria, Staudenraus, Daniel, Marini, Federico, Raifer, Hartmann, Menke, Lisa, Hansal, Lea, Camara, Bärbel, Roth, Edith, Daum, Patrick, Wanzel, Michael, Mernberger, Marco, Nist, Andrea, Bauer, Uta-Maria, Helmprobst, Frederik, Buchholz, Malte, Roth, Katrin, Bastian, Lorenz, Hartmann, Alina M., Baldus, Claudia, Ikuta, Koichi, Neubauer, Andreas, Burchert, Andreas, Jäck, Hans-Martin, Klein, Matthias, Bopp, Tobias, Stiewe, Thorsten, Pagenstecher, Axel, Lohoff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613660/
https://www.ncbi.nlm.nih.gov/pubmed/35459909
http://dx.doi.org/10.1038/s41418-022-01005-z

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