Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnings of this trait and whether it directly drives disease progression is unclear. Here, we identify co-ordinate epigenetic inactivation of two epithelial-specific transcrip...

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Detalles Bibliográficos
Autores principales: Luk, Ian Y., Jenkins, Laura J., Schoffer, Kael L., Ng, Irvin, Tse, Janson W. T., Mouradov, Dmitri, Kaczmarczyk, Stanislaw, Nightingale, Rebecca, Burrows, Allan D., Anderson, Robin L., Arango, Diego, Dopeso, Higinio, Croft, Larry, Richardson, Mark F., Sieber, Oliver M., Liao, Yang, Mooi, Jennifer K., Vukelic, Natalia, Reehorst, Camilla M., Afshar-Sterle, Shoukat, Whitehall, Vicki L. J., Fennell, Lochlan, Abud, Helen E., Tebbutt, Niall C., Phillips, Wayne A., Williams, David S., Shi, Wei, Mielke, Lisa A., Ernst, Matthias, Dhillon, Amardeep S., Clemons, Nicholas J., Mariadason, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613692/
https://www.ncbi.nlm.nih.gov/pubmed/35606410
http://dx.doi.org/10.1038/s41418-022-01016-w

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