Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells

Precise gene editing in human pluripotent stem cells (hPSCs) holds great promise for studying and potentially treating human diseases. Both prime editing and base editing avoid introducing double strand breaks, but low editing efficiencies make those techniques still an arduous process in hPSCs. Her...

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Detalles Bibliográficos
Autores principales: Li, Mu, Zhong, Aaron, Wu, Youjun, Sidharta, Mega, Beaury, Michael, Zhao, Xiaolan, Studer, Lorenz, Zhou, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613702/
https://www.ncbi.nlm.nih.gov/pubmed/36302757
http://dx.doi.org/10.1038/s41467-022-34045-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613702/
https://www.ncbi.nlm.nih.gov/pubmed/36302757
http://dx.doi.org/10.1038/s41467-022-34045-7

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