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Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells
Precise gene editing in human pluripotent stem cells (hPSCs) holds great promise for studying and potentially treating human diseases. Both prime editing and base editing avoid introducing double strand breaks, but low editing efficiencies make those techniques still an arduous process in hPSCs. Her...
Autores principales: | Li, Mu, Zhong, Aaron, Wu, Youjun, Sidharta, Mega, Beaury, Michael, Zhao, Xiaolan, Studer, Lorenz, Zhou, Ting |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613702/ https://www.ncbi.nlm.nih.gov/pubmed/36302757 http://dx.doi.org/10.1038/s41467-022-34045-7 |
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