Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells

One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions o...

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Autores principales: Ivanova, O. K., Sharapova, T. N., Romanova, E. A., Sashchenko, L. P., Yashin, D. V., Georgiev, G. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613720/
https://www.ncbi.nlm.nih.gov/pubmed/36303048
http://dx.doi.org/10.1134/S1607672922050064
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author Ivanova, O. K.
Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
Georgiev, G. P.
author_facet Ivanova, O. K.
Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
Georgiev, G. P.
author_sort Ivanova, O. K.
collection PubMed
description One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and investigation of this subpopulation is important for development of new therapeutic approaches. In this study, we demonstrate that regulatory T cells can migrate along the concentration gradient of Tag7–Mts1 complex, and also they produce agents that induce blood cells migration.
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spelling pubmed-96137202022-10-29 Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells Ivanova, O. K. Sharapova, T. N. Romanova, E. A. Sashchenko, L. P. Yashin, D. V. Georgiev, G. P. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and investigation of this subpopulation is important for development of new therapeutic approaches. In this study, we demonstrate that regulatory T cells can migrate along the concentration gradient of Tag7–Mts1 complex, and also they produce agents that induce blood cells migration. Pleiades Publishing 2022-10-27 2022 /pmc/articles/PMC9613720/ /pubmed/36303048 http://dx.doi.org/10.1134/S1607672922050064 Text en © The Author(s) 2022, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 506, pp. 181–184. © The Author(s), 2022. This article is an open access publication.Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 506, pp. 338–342. https://creativecommons.org/licenses/by/4.0/Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Ivanova, O. K.
Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
Georgiev, G. P.
Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title_full Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title_fullStr Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title_full_unstemmed Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title_short Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
title_sort tag7–mts1 complex activates chemotaxis of regulatory t cells
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613720/
https://www.ncbi.nlm.nih.gov/pubmed/36303048
http://dx.doi.org/10.1134/S1607672922050064
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