An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China

The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 1...

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Detalles Bibliográficos
Autores principales: Zhang, Meiling, Chen, Zhixiao, Zhou, Jienan, Zhao, Xiaonan, Chen, Yaoyao, Sun, Yanhong, Liu, Zhaosheng, Gu, Wenpeng, Luo, Chunrui, Fu, Xiaoqing, Zhao, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Medical Association (CMA) Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613801/
https://www.ncbi.nlm.nih.gov/pubmed/36320663
http://dx.doi.org/10.1016/j.bsheal.2022.10.003
Descripción
Sumario:The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.

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