Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance

Islet β cell dysfunction and insulin resistance are the main pathogenesis of type 2 diabetes (T2D), but the mechanism remains unclear. Here we identify a rs3819316 C > T mutation in lncRNA Reg1cp mainly expressed in islets associated with an increased risk of T2D. Analyses in 16,113 Chinese adult...

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Detalles Bibliográficos
Autores principales: Guo, Wan-Hui, Guo, Qi, Liu, Ya-Lin, Yan, Dan-Dan, Jin, Li, Zhang, Rong, Yan, Jing, Luo, Xiang-Hang, Yang, Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613878/
https://www.ncbi.nlm.nih.gov/pubmed/36302749
http://dx.doi.org/10.1038/s41419-022-05348-w

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