Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is necessary for PKB/Akt-induced muscle hypertrophy, its constant activation alon...

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Detalles Bibliográficos
Autores principales: Kaiser, Marco S., Milan, Giulia, Ham, Daniel J., Lin, Shuo, Oliveri, Filippo, Chojnowska, Kathrin, Tintignac, Lionel A., Mittal, Nitish, Zimmerli, Christian E., Glass, David J., Zavolan, Mihaela, Rüegg, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613904/
https://www.ncbi.nlm.nih.gov/pubmed/36302954
http://dx.doi.org/10.1038/s42003-022-04097-y

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