A novel anti-TNF-α drug ozoralizumab rapidly distributes to inflamed joint tissues in a mouse model of collagen induced arthritis

In clinical studies, the next-generation anti-tumor necrosis factor-alpha (TNF-α) single domain antibody ozoralizumab showed high clinical efficacy shortly after the subcutaneous injection. To elucidate the mechanism underlying the rapid onset of the effects of ozoralizumab, we compared the biodistr...

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Detalles Bibliográficos
Autores principales: Oyama, Shohei, Ebina, Kosuke, Etani, Yuki, Hirao, Makoto, Kyuuma, Masanao, Fujii, Yasuyuki, Iwata, Katsuya, Ogawa, Bunichiro, Hasegawa, Tomoya, Kawano, Sasagu, Nakanishi, Yutaka, Okada, Seiji, Nakata, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613905/
https://www.ncbi.nlm.nih.gov/pubmed/36302840
http://dx.doi.org/10.1038/s41598-022-23152-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613905/
https://www.ncbi.nlm.nih.gov/pubmed/36302840
http://dx.doi.org/10.1038/s41598-022-23152-6

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