Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatm...

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Detalles Bibliográficos
Autores principales: Yan, Ying, Niu, Zhoumin, Sun, Chao, Li, Peng, Shen, Siyi, Liu, Shengnan, Wu, Yuting, Yun, Chuyu, Jiao, Tingying, Jia, Sheng, Li, Yuying, Fang, Zhong-Ze, Zhao, Lin, Wang, Jiqiu, Xie, Cen, Jiang, Changtao, Li, Yan, Feng, Xiaoyun, Hu, Cheng, Jiang, Jingjing, Ying, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613917/
https://www.ncbi.nlm.nih.gov/pubmed/36302774
http://dx.doi.org/10.1038/s41467-022-34258-w

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