Endothelial alpha globin is a nitrite reductase

Resistance artery vasodilation in response to hypoxia is essential for matching tissue oxygen and demand. In hypoxia, erythrocytic hemoglobin tetramers produce nitric oxide through nitrite reduction. We hypothesized that the alpha subunit of hemoglobin expressed in endothelium also facilitates nitri...

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Detalles Bibliográficos
Autores principales: Keller, T. C. Stevenson, Lechauve, Christophe, Keller, Alexander S., Broseghini-Filho, Gilson Brás, Butcher, Joshua T., Askew Page, Henry R., Islam, Aditi, Tan, Zhe Yin, DeLalio, Leon J., Brooks, Steven, Sharma, Poonam, Hong, Kwangseok, Xu, Wenhao, Padilha, Alessandra Simão, Ruddiman, Claire A., Best, Angela K., Macal, Edgar, Kim-Shapiro, Daniel B., Christ, George, Yan, Zhen, Cortese-Krott, Miriam M., Ricart, Karina, Patel, Rakesh, Bender, Timothy P., Sonkusare, Swapnil K., Weiss, Mitchell J., Ackerman, Hans, Columbus, Linda, Isakson, Brant E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613979/
https://www.ncbi.nlm.nih.gov/pubmed/36302779
http://dx.doi.org/10.1038/s41467-022-34154-3

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