Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations

Mutations in presenilin 1 and 2 (PS1 and PS2) cause autosomal dominant familial Alzheimer’s disease (FAD). Ferroptosis has been implicated as a mechanism of neurodegeneration in AD since neocortical iron burden predicts Alzheimer’s disease (AD) progression. We found that loss of the presenilins dram...

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Detalles Bibliográficos
Autores principales: Greenough, Mark A., Lane, Darius J. R., Balez, Rachelle, Anastacio, Helena Targa Dias, Zeng, Zhiwen, Ganio, Katherine, McDevitt, Christopher A., Acevedo, Karla, Belaidi, Abdel Ali, Koistinaho, Jari, Ooi, Lezanne, Ayton, Scott, Bush, Ashley I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613996/
https://www.ncbi.nlm.nih.gov/pubmed/35449212
http://dx.doi.org/10.1038/s41418-022-01003-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613996/
https://www.ncbi.nlm.nih.gov/pubmed/35449212
http://dx.doi.org/10.1038/s41418-022-01003-1

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