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Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome

OBJECTIVE: Regarding pathogenesis, clinical manifestations, at-risk individuals, and diagnostic methods for stratifying patients for therapeutic approaches, our understanding of post-COVID syndrome is limited. Here, we set out to assess sociodemographic and clinical aspects in patients with the long...

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Autores principales: Schulze, Hannah, Charles James, Jeyanthan, Trampe, Nadine, Richter, Daniel, Pakeerathan, Thivya, Siems, Nadine, Ayzenberg, Ilya, Gold, Ralf, Faissner, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614029/
https://www.ncbi.nlm.nih.gov/pubmed/36313487
http://dx.doi.org/10.3389/fneur.2022.979152
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author Schulze, Hannah
Charles James, Jeyanthan
Trampe, Nadine
Richter, Daniel
Pakeerathan, Thivya
Siems, Nadine
Ayzenberg, Ilya
Gold, Ralf
Faissner, Simon
author_facet Schulze, Hannah
Charles James, Jeyanthan
Trampe, Nadine
Richter, Daniel
Pakeerathan, Thivya
Siems, Nadine
Ayzenberg, Ilya
Gold, Ralf
Faissner, Simon
author_sort Schulze, Hannah
collection PubMed
description OBJECTIVE: Regarding pathogenesis, clinical manifestations, at-risk individuals, and diagnostic methods for stratifying patients for therapeutic approaches, our understanding of post-COVID syndrome is limited. Here, we set out to assess sociodemographic and clinical aspects in patients with the long-COVID and post-COVID syndrome. METHODS: We performed a cross-sectional analysis of patients presenting at our specialized university hospital outpatient clinic. We assessed patients' clinical presentation, fatigue, symptoms of depression and anxiety, and impairment of smell. RESULTS: A total of 101 patients were included (73.3% female), of whom 78.2% had a mild course of COVID-19. At presentation, 93.1% suffered from fatigue, 82.2% from impaired concentration, and 79.2% from impaired memory, 53.5% had impaired sleep. The most common secondary diagnosis found in our cohort was thyroid disease. Fatigue analysis showed that 81.3% of female and 58.8% of male patients had severe combined fatigue. Female gender was an independent risk factor for severe fatigue (severe cognitive fatigue OR = 8.045, p = 0.010; severe motor fatigue OR = 7.698, p = 0.013). Males suffered from more depressive symptoms, which correlated positively with the duration of symptom onset. 70.3% of patients with anamnestic smell impairment had hyposmia, and 18.9% were anosmic. INTERPRETATION: Most long-COVID patients suffered from severe fatigue, with the female sex as an independent risk factor. Fatigue was not associated with symptoms of depression or anxiety. Patients with long-COVID symptoms should receive an interdisciplinary diagnostic and therapeutic approach depending on the clinical presentation.
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spelling pubmed-96140292022-10-29 Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome Schulze, Hannah Charles James, Jeyanthan Trampe, Nadine Richter, Daniel Pakeerathan, Thivya Siems, Nadine Ayzenberg, Ilya Gold, Ralf Faissner, Simon Front Neurol Neurology OBJECTIVE: Regarding pathogenesis, clinical manifestations, at-risk individuals, and diagnostic methods for stratifying patients for therapeutic approaches, our understanding of post-COVID syndrome is limited. Here, we set out to assess sociodemographic and clinical aspects in patients with the long-COVID and post-COVID syndrome. METHODS: We performed a cross-sectional analysis of patients presenting at our specialized university hospital outpatient clinic. We assessed patients' clinical presentation, fatigue, symptoms of depression and anxiety, and impairment of smell. RESULTS: A total of 101 patients were included (73.3% female), of whom 78.2% had a mild course of COVID-19. At presentation, 93.1% suffered from fatigue, 82.2% from impaired concentration, and 79.2% from impaired memory, 53.5% had impaired sleep. The most common secondary diagnosis found in our cohort was thyroid disease. Fatigue analysis showed that 81.3% of female and 58.8% of male patients had severe combined fatigue. Female gender was an independent risk factor for severe fatigue (severe cognitive fatigue OR = 8.045, p = 0.010; severe motor fatigue OR = 7.698, p = 0.013). Males suffered from more depressive symptoms, which correlated positively with the duration of symptom onset. 70.3% of patients with anamnestic smell impairment had hyposmia, and 18.9% were anosmic. INTERPRETATION: Most long-COVID patients suffered from severe fatigue, with the female sex as an independent risk factor. Fatigue was not associated with symptoms of depression or anxiety. Patients with long-COVID symptoms should receive an interdisciplinary diagnostic and therapeutic approach depending on the clinical presentation. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614029/ /pubmed/36313487 http://dx.doi.org/10.3389/fneur.2022.979152 Text en Copyright © 2022 Schulze, Charles James, Trampe, Richter, Pakeerathan, Siems, Ayzenberg, Gold and Faissner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Schulze, Hannah
Charles James, Jeyanthan
Trampe, Nadine
Richter, Daniel
Pakeerathan, Thivya
Siems, Nadine
Ayzenberg, Ilya
Gold, Ralf
Faissner, Simon
Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title_full Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title_fullStr Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title_full_unstemmed Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title_short Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome
title_sort cross-sectional analysis of clinical aspects in patients with long-covid and post-covid syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614029/
https://www.ncbi.nlm.nih.gov/pubmed/36313487
http://dx.doi.org/10.3389/fneur.2022.979152
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