Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers

The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose, fatty acids, and amino acids are the specific substrates involved in how an organism maintains metabolic equilibrium. The HADH gene codes for the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH), a crucial e...

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Autores principales: Fang, He, Li, Hanyang, Zhang, Hang, Wang, Shu, Xu, Shuang, Chang, Li, Yang, Yongsheng, Cui, Ranji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614034/
https://www.ncbi.nlm.nih.gov/pubmed/36313354
http://dx.doi.org/10.3389/fphar.2022.1019312
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author Fang, He
Li, Hanyang
Zhang, Hang
Wang, Shu
Xu, Shuang
Chang, Li
Yang, Yongsheng
Cui, Ranji
author_facet Fang, He
Li, Hanyang
Zhang, Hang
Wang, Shu
Xu, Shuang
Chang, Li
Yang, Yongsheng
Cui, Ranji
author_sort Fang, He
collection PubMed
description The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose, fatty acids, and amino acids are the specific substrates involved in how an organism maintains metabolic equilibrium. The HADH gene codes for the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH), a crucial enzyme in fatty acid oxidation that catalyzes the third phase of fatty acid oxidation in mitochondria. Increasing data suggest that HADH is differentially expressed in various types of malignancies and is linked to cancer development and progression. The significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers are summarized in this article. The possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies is also described here.
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spelling pubmed-96140342022-10-29 Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers Fang, He Li, Hanyang Zhang, Hang Wang, Shu Xu, Shuang Chang, Li Yang, Yongsheng Cui, Ranji Front Pharmacol Pharmacology The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose, fatty acids, and amino acids are the specific substrates involved in how an organism maintains metabolic equilibrium. The HADH gene codes for the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH), a crucial enzyme in fatty acid oxidation that catalyzes the third phase of fatty acid oxidation in mitochondria. Increasing data suggest that HADH is differentially expressed in various types of malignancies and is linked to cancer development and progression. The significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers are summarized in this article. The possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies is also described here. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614034/ /pubmed/36313354 http://dx.doi.org/10.3389/fphar.2022.1019312 Text en Copyright © 2022 Fang, Li, Zhang, Wang, Xu, Chang, Yang and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Fang, He
Li, Hanyang
Zhang, Hang
Wang, Shu
Xu, Shuang
Chang, Li
Yang, Yongsheng
Cui, Ranji
Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title_full Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title_fullStr Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title_full_unstemmed Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title_short Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
title_sort short-chain l-3-hydroxyacyl-coa dehydrogenase: a novel vital oncogene or tumor suppressor gene in cancers
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614034/
https://www.ncbi.nlm.nih.gov/pubmed/36313354
http://dx.doi.org/10.3389/fphar.2022.1019312
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