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Cellular milieu in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from normal to malignant PTEC state have remained uncle...

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Autores principales: Raghubar, Arti M., Roberts, Matthew J., Wood, Simon, Healy, Helen G., Kassianos, Andrew J., Mallett, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614096/
https://www.ncbi.nlm.nih.gov/pubmed/36313721
http://dx.doi.org/10.3389/fonc.2022.943583
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author Raghubar, Arti M.
Roberts, Matthew J.
Wood, Simon
Healy, Helen G.
Kassianos, Andrew J.
Mallett, Andrew J.
author_facet Raghubar, Arti M.
Roberts, Matthew J.
Wood, Simon
Healy, Helen G.
Kassianos, Andrew J.
Mallett, Andrew J.
author_sort Raghubar, Arti M.
collection PubMed
description Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from normal to malignant PTEC state have remained unclear. Immunotherapy targeting checkpoints have revolutionized the management of ccRCC, but a sustained clinical response is achieved in only a minority of ccRCC patients. This indicates that our understanding of the mechanisms involved in the malignant transition and resistance to immune checkpoint therapy in ccRCC is unclear. This review examines recent single-cell transcriptomics studies of ccRCC to clarify the transition of PTEC in ccRCC development, and the immune cell types, states, and interactions that may limit the response to targeted immune therapy, and finally suggests stromal cells as key drivers in recurrent and locally invasive ccRCC. These and future single-cell transcriptomics studies will continue to clarify the cellular milieu in the ccRCC microenvironment, thus defining actional clinical, therapeutic, and prognostic characteristics of ccRCC.
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spelling pubmed-96140962022-10-29 Cellular milieu in clear cell renal cell carcinoma Raghubar, Arti M. Roberts, Matthew J. Wood, Simon Healy, Helen G. Kassianos, Andrew J. Mallett, Andrew J. Front Oncol Oncology Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from normal to malignant PTEC state have remained unclear. Immunotherapy targeting checkpoints have revolutionized the management of ccRCC, but a sustained clinical response is achieved in only a minority of ccRCC patients. This indicates that our understanding of the mechanisms involved in the malignant transition and resistance to immune checkpoint therapy in ccRCC is unclear. This review examines recent single-cell transcriptomics studies of ccRCC to clarify the transition of PTEC in ccRCC development, and the immune cell types, states, and interactions that may limit the response to targeted immune therapy, and finally suggests stromal cells as key drivers in recurrent and locally invasive ccRCC. These and future single-cell transcriptomics studies will continue to clarify the cellular milieu in the ccRCC microenvironment, thus defining actional clinical, therapeutic, and prognostic characteristics of ccRCC. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614096/ /pubmed/36313721 http://dx.doi.org/10.3389/fonc.2022.943583 Text en Copyright © 2022 Raghubar, Roberts, Wood, Healy, Kassianos and Mallett https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Raghubar, Arti M.
Roberts, Matthew J.
Wood, Simon
Healy, Helen G.
Kassianos, Andrew J.
Mallett, Andrew J.
Cellular milieu in clear cell renal cell carcinoma
title Cellular milieu in clear cell renal cell carcinoma
title_full Cellular milieu in clear cell renal cell carcinoma
title_fullStr Cellular milieu in clear cell renal cell carcinoma
title_full_unstemmed Cellular milieu in clear cell renal cell carcinoma
title_short Cellular milieu in clear cell renal cell carcinoma
title_sort cellular milieu in clear cell renal cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614096/
https://www.ncbi.nlm.nih.gov/pubmed/36313721
http://dx.doi.org/10.3389/fonc.2022.943583
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