mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model

An mRNA with unmodified nucleosides induces type I interferons (IFN-I) through the stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for anti-tumor immune response remains to be elucidated. In this study, we investigated the immunogenicity and anti-tumor response...

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Detalles Bibliográficos
Autores principales: Sittplangkoon, Chutamath, Alameh, Mohamad-Gabriel, Weissman, Drew, Lin, Paulo J. C., Tam, Ying K., Prompetchara, Eakachai, Palaga, Tanapat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614103/
https://www.ncbi.nlm.nih.gov/pubmed/36311701
http://dx.doi.org/10.3389/fimmu.2022.983000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614103/
https://www.ncbi.nlm.nih.gov/pubmed/36311701
http://dx.doi.org/10.3389/fimmu.2022.983000

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