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Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens

Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigat...

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Autores principales: Habotta, Ola A., Wang, Xiaoyan, Othman, Hamzah, Aljali, Abdulrahman A., Gewaily, Mahmoud, Dawood, Mahmoud, Khafaga, Asmaa, Zaineldin, Amr I., Singla, Rajeev K., Shen, Bairong, Ghamry, Heba I., Elhussieny, Eman, El-Mleeh, Amany, Ibrahim, Samah F., Abdeen, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614105/
https://www.ncbi.nlm.nih.gov/pubmed/36313334
http://dx.doi.org/10.3389/fphar.2022.1026199
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author Habotta, Ola A.
Wang, Xiaoyan
Othman, Hamzah
Aljali, Abdulrahman A.
Gewaily, Mahmoud
Dawood, Mahmoud
Khafaga, Asmaa
Zaineldin, Amr I.
Singla, Rajeev K.
Shen, Bairong
Ghamry, Heba I.
Elhussieny, Eman
El-Mleeh, Amany
Ibrahim, Samah F.
Abdeen, Ahmed
author_facet Habotta, Ola A.
Wang, Xiaoyan
Othman, Hamzah
Aljali, Abdulrahman A.
Gewaily, Mahmoud
Dawood, Mahmoud
Khafaga, Asmaa
Zaineldin, Amr I.
Singla, Rajeev K.
Shen, Bairong
Ghamry, Heba I.
Elhussieny, Eman
El-Mleeh, Amany
Ibrahim, Samah F.
Abdeen, Ahmed
author_sort Habotta, Ola A.
collection PubMed
description Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigating efficacy of SeY on Cu-induced hepatic and renal damage. Cobb chicks aged 1 day were allocated into four experimental groups and offered a basal diet, SeY (0.5 mg/kg), CuSO(4) (300 mg/kg), or SeY plus CuSO(4) in their diets for 42 days. Our results revealed that SeY supplement antagonized significantly the Cu accumulation in livers and kidneys of exposed birds. Marked declines were also detected in the AST, ALT, urea, and creatinine levels, besides marked increases in total protein, glycerides, and cholesterol in the SeY-supplemented group. Moreover, enhancement of cellular antioxidant biomarkers (superoxide dismutase, CAT, GPx, and GSH) along with lowered MDA contents were achieved by SeY in hepatic and renal tissues. Further, SeY exerted a noteworthy anti-inflammatory action as indicated by decreased inflammatory biomarkers (IL-1β and TNF-α) and NO levels in both organs. Noticeable histopathological alterations of both organs further validated the changes in the markers mentioned above. To sum up, our findings indicate that SeY can be considered a potential feed supplement for alleviating Cu-induced hepatic and renal damage in broilers, possibly via activation of antioxidant molecules and lessening the inflammatory stress.
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spelling pubmed-96141052022-10-29 Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens Habotta, Ola A. Wang, Xiaoyan Othman, Hamzah Aljali, Abdulrahman A. Gewaily, Mahmoud Dawood, Mahmoud Khafaga, Asmaa Zaineldin, Amr I. Singla, Rajeev K. Shen, Bairong Ghamry, Heba I. Elhussieny, Eman El-Mleeh, Amany Ibrahim, Samah F. Abdeen, Ahmed Front Pharmacol Pharmacology Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigating efficacy of SeY on Cu-induced hepatic and renal damage. Cobb chicks aged 1 day were allocated into four experimental groups and offered a basal diet, SeY (0.5 mg/kg), CuSO(4) (300 mg/kg), or SeY plus CuSO(4) in their diets for 42 days. Our results revealed that SeY supplement antagonized significantly the Cu accumulation in livers and kidneys of exposed birds. Marked declines were also detected in the AST, ALT, urea, and creatinine levels, besides marked increases in total protein, glycerides, and cholesterol in the SeY-supplemented group. Moreover, enhancement of cellular antioxidant biomarkers (superoxide dismutase, CAT, GPx, and GSH) along with lowered MDA contents were achieved by SeY in hepatic and renal tissues. Further, SeY exerted a noteworthy anti-inflammatory action as indicated by decreased inflammatory biomarkers (IL-1β and TNF-α) and NO levels in both organs. Noticeable histopathological alterations of both organs further validated the changes in the markers mentioned above. To sum up, our findings indicate that SeY can be considered a potential feed supplement for alleviating Cu-induced hepatic and renal damage in broilers, possibly via activation of antioxidant molecules and lessening the inflammatory stress. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614105/ /pubmed/36313334 http://dx.doi.org/10.3389/fphar.2022.1026199 Text en Copyright © 2022 Habotta, Wang, Othman, Aljali, Gewaily, Dawood, Khafaga, Zaineldin, Singla, Shen, Ghamry, Elhussieny, El-Mleeh, Ibrahim and Abdeen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Habotta, Ola A.
Wang, Xiaoyan
Othman, Hamzah
Aljali, Abdulrahman A.
Gewaily, Mahmoud
Dawood, Mahmoud
Khafaga, Asmaa
Zaineldin, Amr I.
Singla, Rajeev K.
Shen, Bairong
Ghamry, Heba I.
Elhussieny, Eman
El-Mleeh, Amany
Ibrahim, Samah F.
Abdeen, Ahmed
Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title_full Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title_fullStr Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title_full_unstemmed Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title_short Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
title_sort selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614105/
https://www.ncbi.nlm.nih.gov/pubmed/36313334
http://dx.doi.org/10.3389/fphar.2022.1026199
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