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The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

Cardiovascular disease (CVD) is a major concern today. Herbal medicine is one helping way to control CVD risks. One conclusive of herbal medicine is Berberine (BBR) and converse about it still exists, to clarify this issue, this meta-analysis was performed. PubMed/Medline, Scopus, and Web of Science...

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Autores principales: Zamani, Mohammad, Zarei, Mahtab, Nikbaf-Shandiz, Mahlagha, Hosseini, Shabnam, Shiraseb, Farideh, Asbaghi, Omid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614282/
https://www.ncbi.nlm.nih.gov/pubmed/36313096
http://dx.doi.org/10.3389/fnut.2022.1013055
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author Zamani, Mohammad
Zarei, Mahtab
Nikbaf-Shandiz, Mahlagha
Hosseini, Shabnam
Shiraseb, Farideh
Asbaghi, Omid
author_facet Zamani, Mohammad
Zarei, Mahtab
Nikbaf-Shandiz, Mahlagha
Hosseini, Shabnam
Shiraseb, Farideh
Asbaghi, Omid
author_sort Zamani, Mohammad
collection PubMed
description Cardiovascular disease (CVD) is a major concern today. Herbal medicine is one helping way to control CVD risks. One conclusive of herbal medicine is Berberine (BBR) and converse about it still exists, to clarify this issue, this meta-analysis was performed. PubMed/Medline, Scopus, and Web of Science were searched for RCTs in adults on the effect of BBR supplementation on CVD risk factors up to July 2022. The pooled results showed BBR significantly reduced triglyceride (WMD = −23.70 mg/dl; 95%CI −30.16, −17.25; P < 0.001), total cholesterol (WMD = −20.64 mg/dl; 95%CI −23.65, −17.63; P < 0.001), low-density lipoprotein WMD = −9.63 mg/dl; 95%CI, −13.87, −5.39; P < 0.001), fasting blood glucose (FBG) (WMD = −7.74 mg/dl; 95%CI −10.79, −4.70; P < 0.001), insulin (WMD = −3.27 mg/dl; 95%CI −4.46,−2.07; P < 0.001), HbA1c (WMD = −0.45%; 95%CI −0.68, −0.23; P < 0.001), HOMA-IR (WMD = −1.04; 95%CI −1.55, −0.52; P < 0.001), systolic blood pressure (WMD = −5.46 mmHg; 95%CI −8.17, −2.76; P < 0.001), weight (WMD = −0.84; 95%CI −1.34,−0.34; P < 0.001), body mass index (WMD = −0.25 kg/m(2); 95%CI −0.46, −0.04; P = 0.020), while increased high-density lipoprotein (HDL) (WMD = 1.37 mg/dl; 95%CI 0.41,2.23; P = 0.005). The optimal dose of BBR was 1 g/day for TG, TC, and weight, 1.8 g/day for insulin and HOMA-IR, and 5 g/day for HDL. FBG's most efficient time frame was 40 weeks from the beginning of supplementation, whereas DBP and waist circumference was 50 weeks. In conclusion, the lipid profile, FBG balance, obesity parameters, and SBP were improved with BBR supplementation. SYSTEMATIC REVIEW REGISTRATION: CRD42022347004.
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spelling pubmed-96142822022-10-29 The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis Zamani, Mohammad Zarei, Mahtab Nikbaf-Shandiz, Mahlagha Hosseini, Shabnam Shiraseb, Farideh Asbaghi, Omid Front Nutr Nutrition Cardiovascular disease (CVD) is a major concern today. Herbal medicine is one helping way to control CVD risks. One conclusive of herbal medicine is Berberine (BBR) and converse about it still exists, to clarify this issue, this meta-analysis was performed. PubMed/Medline, Scopus, and Web of Science were searched for RCTs in adults on the effect of BBR supplementation on CVD risk factors up to July 2022. The pooled results showed BBR significantly reduced triglyceride (WMD = −23.70 mg/dl; 95%CI −30.16, −17.25; P < 0.001), total cholesterol (WMD = −20.64 mg/dl; 95%CI −23.65, −17.63; P < 0.001), low-density lipoprotein WMD = −9.63 mg/dl; 95%CI, −13.87, −5.39; P < 0.001), fasting blood glucose (FBG) (WMD = −7.74 mg/dl; 95%CI −10.79, −4.70; P < 0.001), insulin (WMD = −3.27 mg/dl; 95%CI −4.46,−2.07; P < 0.001), HbA1c (WMD = −0.45%; 95%CI −0.68, −0.23; P < 0.001), HOMA-IR (WMD = −1.04; 95%CI −1.55, −0.52; P < 0.001), systolic blood pressure (WMD = −5.46 mmHg; 95%CI −8.17, −2.76; P < 0.001), weight (WMD = −0.84; 95%CI −1.34,−0.34; P < 0.001), body mass index (WMD = −0.25 kg/m(2); 95%CI −0.46, −0.04; P = 0.020), while increased high-density lipoprotein (HDL) (WMD = 1.37 mg/dl; 95%CI 0.41,2.23; P = 0.005). The optimal dose of BBR was 1 g/day for TG, TC, and weight, 1.8 g/day for insulin and HOMA-IR, and 5 g/day for HDL. FBG's most efficient time frame was 40 weeks from the beginning of supplementation, whereas DBP and waist circumference was 50 weeks. In conclusion, the lipid profile, FBG balance, obesity parameters, and SBP were improved with BBR supplementation. SYSTEMATIC REVIEW REGISTRATION: CRD42022347004. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614282/ /pubmed/36313096 http://dx.doi.org/10.3389/fnut.2022.1013055 Text en Copyright © 2022 Zamani, Zarei, Nikbaf-Shandiz, Hosseini, Shiraseb and Asbaghi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zamani, Mohammad
Zarei, Mahtab
Nikbaf-Shandiz, Mahlagha
Hosseini, Shabnam
Shiraseb, Farideh
Asbaghi, Omid
The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title_full The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title_fullStr The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title_full_unstemmed The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title_short The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
title_sort effects of berberine supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614282/
https://www.ncbi.nlm.nih.gov/pubmed/36313096
http://dx.doi.org/10.3389/fnut.2022.1013055
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