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Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension
A Disintegrin and Metalloprotease 17 (ADAM17), also called tumor necrosis factor-ɑ (TNF-ɑ) convertase (TACE), is a well-known protease involved in the sheddase of growth factors, chemokines and cytokines. ADAM17 is also enrolled in hypertension, especially by shedding of angiotensin converting enzym...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614329/ https://www.ncbi.nlm.nih.gov/pubmed/36310604 http://dx.doi.org/10.3389/fmolb.2022.1032177 |
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author | da Silva, Mirelly Cunha dos Santos, Vanessa Maria da Silva, Matheus Vinícius B. Prazeres, Tereza Cristina M. M. Cartágenes, Maria do Socorro S. Calzerra, Natália Tabosa M. de Queiroz, Thyago Moreira |
author_facet | da Silva, Mirelly Cunha dos Santos, Vanessa Maria da Silva, Matheus Vinícius B. Prazeres, Tereza Cristina M. M. Cartágenes, Maria do Socorro S. Calzerra, Natália Tabosa M. de Queiroz, Thyago Moreira |
author_sort | da Silva, Mirelly Cunha |
collection | PubMed |
description | A Disintegrin and Metalloprotease 17 (ADAM17), also called tumor necrosis factor-ɑ (TNF-ɑ) convertase (TACE), is a well-known protease involved in the sheddase of growth factors, chemokines and cytokines. ADAM17 is also enrolled in hypertension, especially by shedding of angiotensin converting enzyme type 2 (ACE2) leading to impairment of angiotensin 1–7 [Ang-(1–7)] production and injury in vasodilation, induction of renal damage and cardiac hypertrophy. Activation of Mas receptor (MasR) by binding of Ang-(1–7) induces an increase in the nitric oxide (NO) gaseous molecule, which is an essential factor of vascular homeostasis and blood pressure control. On the other hand, TNF-ɑ has demonstrated to stimulate a decrease in nitric oxide bioavailability, triggering a disrupt in endothelium-dependent vasorelaxation. In spite of the previous studies, little knowledge is available about the involvement of the metalloprotease 17 and the NO pathways. Here we will provide an overview of the role of ADAM17 and Its mechanisms implicated with the NO formation. |
format | Online Article Text |
id | pubmed-9614329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96143292022-10-29 Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension da Silva, Mirelly Cunha dos Santos, Vanessa Maria da Silva, Matheus Vinícius B. Prazeres, Tereza Cristina M. M. Cartágenes, Maria do Socorro S. Calzerra, Natália Tabosa M. de Queiroz, Thyago Moreira Front Mol Biosci Molecular Biosciences A Disintegrin and Metalloprotease 17 (ADAM17), also called tumor necrosis factor-ɑ (TNF-ɑ) convertase (TACE), is a well-known protease involved in the sheddase of growth factors, chemokines and cytokines. ADAM17 is also enrolled in hypertension, especially by shedding of angiotensin converting enzyme type 2 (ACE2) leading to impairment of angiotensin 1–7 [Ang-(1–7)] production and injury in vasodilation, induction of renal damage and cardiac hypertrophy. Activation of Mas receptor (MasR) by binding of Ang-(1–7) induces an increase in the nitric oxide (NO) gaseous molecule, which is an essential factor of vascular homeostasis and blood pressure control. On the other hand, TNF-ɑ has demonstrated to stimulate a decrease in nitric oxide bioavailability, triggering a disrupt in endothelium-dependent vasorelaxation. In spite of the previous studies, little knowledge is available about the involvement of the metalloprotease 17 and the NO pathways. Here we will provide an overview of the role of ADAM17 and Its mechanisms implicated with the NO formation. Frontiers Media S.A. 2022-10-14 /pmc/articles/PMC9614329/ /pubmed/36310604 http://dx.doi.org/10.3389/fmolb.2022.1032177 Text en Copyright © 2022 da Silva, dos Santos, da Silva, Prazeres, Cartágenes, Calzerra and de Queiroz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences da Silva, Mirelly Cunha dos Santos, Vanessa Maria da Silva, Matheus Vinícius B. Prazeres, Tereza Cristina M. M. Cartágenes, Maria do Socorro S. Calzerra, Natália Tabosa M. de Queiroz, Thyago Moreira Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title | Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title_full | Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title_fullStr | Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title_full_unstemmed | Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title_short | Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension |
title_sort | involvement of shedding induced by adam17 on the nitric oxide pathway in hypertension |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614329/ https://www.ncbi.nlm.nih.gov/pubmed/36310604 http://dx.doi.org/10.3389/fmolb.2022.1032177 |
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