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Pharmacogenomic-guided clozapine administration based on HLA-DQB1, HLA-B and SLCO1B3-SLCO1B7 variants: an effectiveness and cost-effectiveness analysis

The identification of pharmacogenetic factors that increase the susceptibility to clozapine-induced agranulocytosis or granulocytopenia (CIAG) has received increasing interest. The SLCO1B3-SCLO1B7 variant (rs149104283) and single amino acid changes in human leukocyte antigen (HLA) HLA-DQB1 (126Q) an...

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Detalles Bibliográficos
Autores principales:	Ninomiya, Kohei, Saito, Takeo, Ikeda, Masashi, Iwata, Nakao, Girardin, François R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614368/ https://www.ncbi.nlm.nih.gov/pubmed/36313369 http://dx.doi.org/10.3389/fphar.2022.1016669

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