Self-organization in amoeboid motility

Amoeboid motility has come to refer to a spectrum of cell migration modes enabling a cell to move in the absence of strong, specific adhesion. To do so, cells have evolved a range of motile surface movements whose physical principles are now coming into view. In response to external cues, many cells—and some single-celled-organisms—have the capacity to turn off their default migration mode. and switch to an amoeboid mode. This implies a restructuring of the migration machinery at the cell scale and suggests a close link between cell polarization and migration mediated by self-organizing mechanisms. Here, I review recent theoretical models with the aim of providing an integrative, physical picture of amoeboid migration.