Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line

The combination of high-resolution LC-MS untargeted metabolomics with stable isotope-resolved tracing is a promising approach for the global exploration of metabolic pathway activities. In our established workflow we combine targeted isotopologue feature extraction with the non-targeted X(13)CMS rou...

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Detalles Bibliográficos
Autores principales: Lackner, Marcel, Neef, Sylvia K., Winter, Stefan, Beer-Hammer, Sandra, Nürnberg, Bernd, Schwab, Matthias, Hofmann, Ute, Haag, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614656/
https://www.ncbi.nlm.nih.gov/pubmed/36310598
http://dx.doi.org/10.3389/fmolb.2022.1004602

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