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Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired proliferation at 37°C–39°C, and the capacity to induce...

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Detalles Bibliográficos
Autores principales:	Yoshida, Akiho, Okamura, Shinya, Torii, Shiho, Komatsu, Sayuri, Miyazato, Paola, Sasaki, Hitomi, Ueno, Shiori, Suzuki, Hidehiko, Kamitani, Wataru, Ono, Chikako, Matsuura, Yoshiharu, Takekawa, Shiro, Yamanishi, Koichi, Ebina, Hirotaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614708/ https://www.ncbi.nlm.nih.gov/pubmed/36320329 http://dx.doi.org/10.1016/j.isci.2022.105412

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