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Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings
The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions durin...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614711/ https://www.ncbi.nlm.nih.gov/pubmed/36312555 http://dx.doi.org/10.3389/fbioe.2022.987650 |
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author | Cazzagon, V. Giubilato, E. Bonetto, A. Blosi, M. Zanoni, I. Costa, A. L. Vineis, C. Varesano, A. Marcomini, A. Hristozov, D. Semenzin, E. Badetti, E. |
author_facet | Cazzagon, V. Giubilato, E. Bonetto, A. Blosi, M. Zanoni, I. Costa, A. L. Vineis, C. Varesano, A. Marcomini, A. Hristozov, D. Semenzin, E. Badetti, E. |
author_sort | Cazzagon, V. |
collection | PubMed |
description | The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions during their use or the persistence of unused NPs in the wound dressing that can cause a release of Ag during the end-of-life of the product. For this reason, a Safe-by-Design procedure has been developed to reduce potential environmental risks while optimizing functionality and costs of wound dressings containing Ag NPs. The SbD procedure is based on ad-hoc criteria (e.g., mechanical strength, antibacterial effect, leaching of Ag from the product immersed in environmental media) and permits to identify the best one among five pre-market alternatives. A ranking of the SbD alternatives was obtained and the safer solution was selected based on the selected SbD criteria. The SbD framework was also applied to commercial wound dressings to compare the SbD alternatives with products already on the market. The iterative procedure permitted to exclude one of the alternatives (based on its low mechanical strength) and proved to be an effective approach that can be replicated to support the ranking, prioritisation, and selection of the most promising options early in the innovation process of nano-enabled medical devices as well as to encourage the production of medical devices safer for the environment. |
format | Online Article Text |
id | pubmed-9614711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96147112022-10-29 Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings Cazzagon, V. Giubilato, E. Bonetto, A. Blosi, M. Zanoni, I. Costa, A. L. Vineis, C. Varesano, A. Marcomini, A. Hristozov, D. Semenzin, E. Badetti, E. Front Bioeng Biotechnol Bioengineering and Biotechnology The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions during their use or the persistence of unused NPs in the wound dressing that can cause a release of Ag during the end-of-life of the product. For this reason, a Safe-by-Design procedure has been developed to reduce potential environmental risks while optimizing functionality and costs of wound dressings containing Ag NPs. The SbD procedure is based on ad-hoc criteria (e.g., mechanical strength, antibacterial effect, leaching of Ag from the product immersed in environmental media) and permits to identify the best one among five pre-market alternatives. A ranking of the SbD alternatives was obtained and the safer solution was selected based on the selected SbD criteria. The SbD framework was also applied to commercial wound dressings to compare the SbD alternatives with products already on the market. The iterative procedure permitted to exclude one of the alternatives (based on its low mechanical strength) and proved to be an effective approach that can be replicated to support the ranking, prioritisation, and selection of the most promising options early in the innovation process of nano-enabled medical devices as well as to encourage the production of medical devices safer for the environment. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9614711/ /pubmed/36312555 http://dx.doi.org/10.3389/fbioe.2022.987650 Text en Copyright © 2022 Cazzagon, Giubilato, Bonetto, Blosi, Zanoni, Costa, Vineis, Varesano, Marcomini, Hristozov, Semenzin and Badetti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Cazzagon, V. Giubilato, E. Bonetto, A. Blosi, M. Zanoni, I. Costa, A. L. Vineis, C. Varesano, A. Marcomini, A. Hristozov, D. Semenzin, E. Badetti, E. Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title_full | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title_fullStr | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title_full_unstemmed | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title_short | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
title_sort | identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614711/ https://www.ncbi.nlm.nih.gov/pubmed/36312555 http://dx.doi.org/10.3389/fbioe.2022.987650 |
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