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Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study

BACKGROUND: There is a lack of studies regarding radiotherapy (RT) in patients with gallbladder cancer (GBC) on the survival benefit after surgery and nonsurgical treatment. Therefore, this study evaluated the impact of external beam RT on the overall survival (OS) of patients with GBC in a real-wor...

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Autores principales: Song, Jiazhao, Kang, Xiaoli, Di, Yupeng, Ren, Gang, Wang, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614712/
https://www.ncbi.nlm.nih.gov/pubmed/36311614
http://dx.doi.org/10.3389/fpubh.2022.1012142
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author Song, Jiazhao
Kang, Xiaoli
Di, Yupeng
Ren, Gang
Wang, Yingjie
author_facet Song, Jiazhao
Kang, Xiaoli
Di, Yupeng
Ren, Gang
Wang, Yingjie
author_sort Song, Jiazhao
collection PubMed
description BACKGROUND: There is a lack of studies regarding radiotherapy (RT) in patients with gallbladder cancer (GBC) on the survival benefit after surgery and nonsurgical treatment. Therefore, this study evaluated the impact of external beam RT on the overall survival (OS) of patients with GBC in a real-world setting. METHODS: Patients with GBC enrolled from the Surveillance, Epidemiology, and End Results (SEER) database were examined through Kaplan–Meier survival curves and multivariable Cox regression analyses. RESULTS: A total of 7,866 patients with GBC were screened for the current analysis, of whom 2,130 (27.1%) did not undergo RT or surgery, 209 (2.7%) underwent RT, 4,511 (57.3%) underwent surgery, and 1,016 (12.9%) underwent both RT and surgery. The median OS times were 4 months, 8 months, 16 months, and 22 months (p < 0.0001). OS was significantly different between adjuvant RT (p = 0.0002) and palliative RT (p < 0.0001). Multifactorial analysis (controlling for age, sex, year of diagnosis, marital status, race, grade, and stage) showed that both adjuvant RT (surgery and adjuvant RT vs. surgery alone; HR, 0.75; 95% CI, 0.69–0.82, p < 0.001) and palliative RT (RT alone vs. no treatment; HR, 0.80; 95% CI, 0.69–0.92, p = 0.003) had a significant impact on patient OS. The results remained stable following sensitivity analyses. CONCLUSION: The study results indicate that adjuvant and palliative radiation treatment was associated with a survival benefit. GBC patients can derive a survival benefit from external beam RT.
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spelling pubmed-96147122022-10-29 Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study Song, Jiazhao Kang, Xiaoli Di, Yupeng Ren, Gang Wang, Yingjie Front Public Health Public Health BACKGROUND: There is a lack of studies regarding radiotherapy (RT) in patients with gallbladder cancer (GBC) on the survival benefit after surgery and nonsurgical treatment. Therefore, this study evaluated the impact of external beam RT on the overall survival (OS) of patients with GBC in a real-world setting. METHODS: Patients with GBC enrolled from the Surveillance, Epidemiology, and End Results (SEER) database were examined through Kaplan–Meier survival curves and multivariable Cox regression analyses. RESULTS: A total of 7,866 patients with GBC were screened for the current analysis, of whom 2,130 (27.1%) did not undergo RT or surgery, 209 (2.7%) underwent RT, 4,511 (57.3%) underwent surgery, and 1,016 (12.9%) underwent both RT and surgery. The median OS times were 4 months, 8 months, 16 months, and 22 months (p < 0.0001). OS was significantly different between adjuvant RT (p = 0.0002) and palliative RT (p < 0.0001). Multifactorial analysis (controlling for age, sex, year of diagnosis, marital status, race, grade, and stage) showed that both adjuvant RT (surgery and adjuvant RT vs. surgery alone; HR, 0.75; 95% CI, 0.69–0.82, p < 0.001) and palliative RT (RT alone vs. no treatment; HR, 0.80; 95% CI, 0.69–0.92, p = 0.003) had a significant impact on patient OS. The results remained stable following sensitivity analyses. CONCLUSION: The study results indicate that adjuvant and palliative radiation treatment was associated with a survival benefit. GBC patients can derive a survival benefit from external beam RT. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9614712/ /pubmed/36311614 http://dx.doi.org/10.3389/fpubh.2022.1012142 Text en Copyright © 2022 Song, Kang, Di, Ren and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Song, Jiazhao
Kang, Xiaoli
Di, Yupeng
Ren, Gang
Wang, Yingjie
Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title_full Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title_fullStr Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title_full_unstemmed Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title_short Associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: A population-based study
title_sort associations between external beam radiotherapy and overall survival in patients with gallbladder cancer: a population-based study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614712/
https://www.ncbi.nlm.nih.gov/pubmed/36311614
http://dx.doi.org/10.3389/fpubh.2022.1012142
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