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The staphylococcal inhibitory protein SPIN binds to human myeloperoxidase with picomolar affinity but only dampens halide oxidation

The heme enzyme myeloperoxidase (MPO) is one of the key players in the neutrophil-mediated killing of invading pathogens as part of the innate immune system. MPO generates antimicrobial oxidants, which indiscriminately and effectively kill phagocytosed pathogens. Staphylococcus aureus, however, is a...

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Detalles Bibliográficos
Autores principales:	Leitgeb, Urban, Furtmüller, Paul G., Hofbauer, Stefan, Brito, Jose A., Obinger, Christian, Pfanzagl, Vera
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615034/ https://www.ncbi.nlm.nih.gov/pubmed/36150500 http://dx.doi.org/10.1016/j.jbc.2022.102514

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