Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity

[Image: see text] Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to off-target immune activation. Here, we developed a polymeric delivery platform that binds excess unpaired cysteines on tumor cell...

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Detalles Bibliográficos
Autores principales: Slezak, Anna J., Mansurov, Aslan, Raczy, Michal M., Chang, Kevin, Alpar, Aaron T., Lauterbach, Abigail L., Wallace, Rachel P., Weathered, Rachel K., Medellin, Jorge E.G., Battistella, Claudia, Gray, Laura T., Marchell, Tiffany M., Gomes, Suzana, Swartz, Melody A., Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615125/
https://www.ncbi.nlm.nih.gov/pubmed/36313164
http://dx.doi.org/10.1021/acscentsci.2c00704

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