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An electroencephalogram biomarker of fentanyl drug effects
Opioid drugs influence multiple brain circuits in parallel to produce analgesia as well as side effects, including respiratory depression. At present, we do not have real-time clinical biomarkers of these brain effects. Here, we describe the results of an experiment to characterize the electroenceph...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615126/ https://www.ncbi.nlm.nih.gov/pubmed/36329725 http://dx.doi.org/10.1093/pnasnexus/pgac158 |
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author | Balanza, Gustavo A Bharadwaj, Kishore M Mullen, Andrew C Beck, Amanda M Work, Erin C McGovern, Francis J Houle, Timothy T Eric, T Pierce Purdon, Patrick L |
author_facet | Balanza, Gustavo A Bharadwaj, Kishore M Mullen, Andrew C Beck, Amanda M Work, Erin C McGovern, Francis J Houle, Timothy T Eric, T Pierce Purdon, Patrick L |
author_sort | Balanza, Gustavo A |
collection | PubMed |
description | Opioid drugs influence multiple brain circuits in parallel to produce analgesia as well as side effects, including respiratory depression. At present, we do not have real-time clinical biomarkers of these brain effects. Here, we describe the results of an experiment to characterize the electroencephalographic signatures of fentanyl in humans. We find that increasing concentrations of fentanyl induce a frontal theta band (4 to 8 Hz) signature distinct from slow-delta oscillations related to sleep and sedation. We also report that respiratory depression, quantified by decline in an index of instantaneous minute ventilation, occurs at ≈1700-fold lower concentrations than those that produce sedation as measured by reaction time. The electroencephalogram biomarker we describe could facilitate real-time monitoring of opioid drug effects and enable more precise and personalized opioid administration. |
format | Online Article Text |
id | pubmed-9615126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96151262022-11-01 An electroencephalogram biomarker of fentanyl drug effects Balanza, Gustavo A Bharadwaj, Kishore M Mullen, Andrew C Beck, Amanda M Work, Erin C McGovern, Francis J Houle, Timothy T Eric, T Pierce Purdon, Patrick L PNAS Nexus Biological, Health, and Medical Sciences Opioid drugs influence multiple brain circuits in parallel to produce analgesia as well as side effects, including respiratory depression. At present, we do not have real-time clinical biomarkers of these brain effects. Here, we describe the results of an experiment to characterize the electroencephalographic signatures of fentanyl in humans. We find that increasing concentrations of fentanyl induce a frontal theta band (4 to 8 Hz) signature distinct from slow-delta oscillations related to sleep and sedation. We also report that respiratory depression, quantified by decline in an index of instantaneous minute ventilation, occurs at ≈1700-fold lower concentrations than those that produce sedation as measured by reaction time. The electroencephalogram biomarker we describe could facilitate real-time monitoring of opioid drug effects and enable more precise and personalized opioid administration. Oxford University Press 2022-08-30 /pmc/articles/PMC9615126/ /pubmed/36329725 http://dx.doi.org/10.1093/pnasnexus/pgac158 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Biological, Health, and Medical Sciences Balanza, Gustavo A Bharadwaj, Kishore M Mullen, Andrew C Beck, Amanda M Work, Erin C McGovern, Francis J Houle, Timothy T Eric, T Pierce Purdon, Patrick L An electroencephalogram biomarker of fentanyl drug effects |
title | An electroencephalogram biomarker of fentanyl drug effects |
title_full | An electroencephalogram biomarker of fentanyl drug effects |
title_fullStr | An electroencephalogram biomarker of fentanyl drug effects |
title_full_unstemmed | An electroencephalogram biomarker of fentanyl drug effects |
title_short | An electroencephalogram biomarker of fentanyl drug effects |
title_sort | electroencephalogram biomarker of fentanyl drug effects |
topic | Biological, Health, and Medical Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615126/ https://www.ncbi.nlm.nih.gov/pubmed/36329725 http://dx.doi.org/10.1093/pnasnexus/pgac158 |
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